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Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter.
Gene Name: | Rho GTPase activating protein 22 |
Synonyms: | ARHGAP22, RhoGAP2, RhoGap22 |
Target Sequences: | NM_021226 NP_067049.2 Q7Z5H3 |
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