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May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
Gene Name: | arginase 2 |
Synonyms: | ARG2, Arginase II, Kidney arginase, Nonhepatic arginase, Kidney-type arginase, L-arginine ureahydrolase, Type II arginase, Arginase 2, Arginase, type II, Arginase-2, mitochondrial, L-arginine amidinohydrolase, Non-hepatic arginase |
Target Sequences: | NM_001172 NP_001163.1 P78540 |
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