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APPL1 / APPL
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
APPL1 / APPL has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.
| Gene Name: | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 |
| Synonyms: | APPL1, Dip13-alpha, DIP13A, DIP13alpha, AKT2 interactor, KIAA1428, APPL |
| Target Sequences: | NM_012096 NP_036228.1 Q9UKG1 |
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