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APPL1 / APPL

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

APPL1 / APPL has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.

Gene Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
Synonyms: APPL1, Dip13-alpha, DIP13A, DIP13alpha, AKT2 interactor, KIAA1428, APPL
Target Sequences: NM_012096 NP_036228.1 Q9UKG1

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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).