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APP / Beta Amyloid Precursor

amyloid beta (A4) precursor protein

Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu2+-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu2+ ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.

Gene Name: amyloid beta (A4) precursor protein
Family/Subfamily: Amyloid precursor protein , Not assigned-Other
Synonyms: APP, ABPP, A4, ABETA, AD1, Alzheimer disease, Amyloid beta, Beta-amyloid peptide, APPI, Beta amyloid, CVAP, AAA, PN2, PreA4, Amyloid beta A4 protein, Peptidase nexin-II, CTFgamma, PN-II, Protease nexin-II
Target Sequences: NM_000484 NP_000475.1 P05067

Publications (3)

1
Platelets are responsible for the accumulation of ß-amyloid in blood clots inside and around blood vessels in mouse brain after thrombosis. Kucheryavykh LY, Dávila-Rodríguez J, Rivera-Aponte DE, Zueva LV, Washington AV, Sanabria P, Inyushin MY. Brain research bulletin. 2017 January;128:98-105. (Human) [Full Text Article] [PubMed:27908798] [PMC:PMC5205543] Related Antibodies: LS-C181965.
2
Amyloid Beta Peptide Is Released during Thrombosis in the Skin. Kucheryavykh LY, Kucheryavykh YV, Washington AV, Inyushin MY. International journal of molecular sciences. 2018 June;19:pii: E1705. (Human) [Full Text Article] [PubMed:29890636] [PMC:PMC6032379] Related Antibodies: LS-C181965.
3
Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer's disease mice. Sandro Alves, Guillaume Churlaud, Mickael Audrain, Kristin Michaelsen-Preusse, Romain Fol, Benoit Souchet, Jérôme Braudeau, Martin Korte, David Klatzmann, Nathalie Cartier. Brain : a journal of neurology. 2017 March;140:826-842. [Full Text Article] [PubMed:28003243]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).