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APOE / Apolipoprotein E

apolipoprotein E

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.

Gene Name: apolipoprotein E
Synonyms: APOE, AD2, Apo-E, Apolipoprotein E3, Apolipoprotein E, LDLCQ5, LPG
Target Sequences: NM_000041 NP_000032.1 P02649

Publications (2)

1
A proteomic approach for the diagnosis of bacterial meningitis. Jesse S, Steinacker P, Lehnert S, Sdzuj M, Cepek L, Tumani H, Jahn O, Schmidt H, Otto M. PloS one. 2010 5:e10079. (WB) [PubMed:20386697] [PMC:PMC2851643]
2
Longterm Increased S100B Enhances Hippocampal Progenitor Cell Proliferation in a Transgenic Mouse Model. Leticia Rodrigues, Krista Minéia Wartchow, Michael Buchfelder, Diogo Onofre Souza, Carlos-Alberto Gonçalves, Andrea Kleindienst. International journal of molecular sciences. 2022 August;23: [Full Text Article] [PubMed:36076994] [PMC:PMC9455494]

☰ Filters
Products
Proteins (20)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (3)
Recombinant (16)
APOE / Apolipoprotein E (20)
SDS-PAGE (1)
No (20)
10His, N-terminus + Myc, C-terminus (1)
10His-B2M, N-terminus + Myc, C-terminus (1)
10His-SUMO, N-terminus + Myc, C-terminus (1)
6His, C-terminus (4)
6His, N-terminus (4)
GST-6His, N-terminus (1)
His, N-Terminal (1)
His,N-terminus + GST (1)
His-S (1)
His-T7 (1)
Myc-DDK (Flag) (3)
TRX-His, N-terminus (1)
Dog (1)
Human (9)
Mouse (5)
Rabbit (3)
Rat (1)
293T Cells (1)
E. coli (9)
HEK 293 Cells (6)
Human Cells (1)
Mammalian Cells (2)
Yeast (1)
Purified (3)
Low endotoxin level (4)
APOE / Apolipoprotein E Protein
Select
Yeast
6His, N-terminus
35.9 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
Select
HEK 293 Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
35.3kD
10 µg/$218; 50 µg/$240; 500 µg/$343; 1 mg/$409
Select
E. coli
6His, N-terminus
38 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
APOE / Apolipoprotein E Protein
Select
HEK 293 Cells
His, N-Terminal
~37 kDa
10 µg/$289; 50 µg/$360
APOE / Apolipoprotein E Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
10His, N-terminus + Myc, C-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
35kD
10 µg/$288; 50 µg/$516; 500 µg/$1,262; 1 mg/$1,627
APOE / Apolipoprotein E Protein - Recombinant Apolipoprotein E By SDS-PAGE
Select
E. coli
His,N-terminus + GST
49.6 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
APOE / Apolipoprotein E Protein - Recombinant Apolipoprotein E By SDS-PAGE
Select
E. coli
GST-6His, N-terminus
50.0 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
APOE / Apolipoprotein E Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
36.15 kDa
100 µg/$494
Select
E. coli
TRX-His, N-terminus
SDS-PAGE
The recombinant human APOE/Trx fusion protein consisting of 458 amino acids and has a calculated molecular mass of 51.3 kDa. It migrates as an approximately 46 kDa band in SDS-PAGE under reducing conditions.
1 mg/$519; 100 µg/$271
APOE / Apolipoprotein E Protein - Recombinant Apolipoprotein E By SDS-PAGE
Select
E. coli
His-S
23.7 kDa
10 µg/$292; 50 µg/$512; 100 µg/$817; 200 µg/$1,018; 1 mg/$2,168; 500 µg/$1,690; 5 mg/$3,571; 2 mg/$2,359
Select
HEK 293 Cells
6His, N-terminus
37 kDa
100 µg/$298
Select
HEK 293 Cells
6His, N-terminus
37 kDa
200 µl/$283
Select
293T Cells
Myc-DDK (Flag)
36.15 kDa
20 µg/$150
APOE / Apolipoprotein E Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
10His-SUMO, N-terminus + Myc, C-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
APOE / Apolipoprotein E Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
10His-B2M, N-terminus + Myc, C-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
APOE / Apolipoprotein E Protein - Purified recombinant protein APOE was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
34.2 kDa
20 µg/$1,107
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
35.0 kDa
10 µg/$286; 50 µg/$507
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
35.3 kDa
10 µg/$220; 50 µg/$240
APOE / Apolipoprotein E Protein - Recombinant Apolipoprotein E By SDS-PAGE
Select
E. coli
His-T7
23.0 kDa
10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).