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APOE / Apolipoprotein E

apolipoprotein E

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.

Gene Name: apolipoprotein E
Synonyms: APOE, AD2, Apo-E, Apolipoprotein E3, Apolipoprotein E, LDLCQ5, LPG
Target Sequences: NM_000041 NP_000032.1 P02649

Publications (2)

1
A proteomic approach for the diagnosis of bacterial meningitis. Jesse S, Steinacker P, Lehnert S, Sdzuj M, Cepek L, Tumani H, Jahn O, Schmidt H, Otto M. PloS one. 2010 5:e10079. (WB) [PubMed:20386697] [PMC:PMC2851643]
2
Longterm Increased S100B Enhances Hippocampal Progenitor Cell Proliferation in a Transgenic Mouse Model. Leticia Rodrigues, Krista Minéia Wartchow, Michael Buchfelder, Diogo Onofre Souza, Carlos-Alberto Gonçalves, Andrea Kleindienst. International journal of molecular sciences. 2022 August;23: [Full Text Article] [PubMed:36076994] [PMC:PMC9455494]

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Antibodies (143)
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APOE / Apolipoprotein E (143)
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No (143)
APOE / Apolipoprotein E Antibody - Anti-APOE / Apolipoprotein E antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Neuroscience
APOE / Apolipoprotein E Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
APOE / Apolipoprotein E Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
APOE / Apolipoprotein E Goat anti-Human Polyclonal (aa305-317) Antibody
Human
IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
APOE / Apolipoprotein E Antibody - Anti-APOE / Apolipoprotein E antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Neuroscience
APOE / Apolipoprotein E Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
APOE / Apolipoprotein E Antibody - Anti-APOE / Apolipoprotein E antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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APOE / Apolipoprotein E Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Human
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
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APOE / Apolipoprotein E Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IHC, IHC-Fr
Unconjugated
1 ml/$549
APOE / Apolipoprotein E Antibody - Adrenal, Human: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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APOE / Apolipoprotein E Mouse anti-Human Monoclonal (Biotin) (WUE-4) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
APOE / Apolipoprotein E Antibody - Adrenal, Human: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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APOE / Apolipoprotein E Mouse anti-Human Monoclonal (DY488) (WUE-4) Antibody
Human
ELISA, IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
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APOE / Apolipoprotein E Mouse anti-Human Monoclonal Antibody
Human
WB
Unconjugated
100 µl/$838
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APOE / Apolipoprotein E Goat anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
1 mg/$626
APOE / Apolipoprotein E Antibody
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APOE / Apolipoprotein E Mouse anti-Human Monoclonal (1F9) Antibody
Human
IHC, IP, WB
Unconjugated
100 µg/$454
APOE / Apolipoprotein E Antibody - Western Blot (non-reducing) of Apolipoprotein E / APOE antibody
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APOE / Apolipoprotein E Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
APOE / Apolipoprotein E Antibody - Biotinylated Anti-Human ApoE3 Western Blot Unreduced
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APOE / Apolipoprotein E Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
APOE / Apolipoprotein E Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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APOE / Apolipoprotein E Rabbit anti-Human Polyclonal (aa81-130) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
APOE / Apolipoprotein E Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Neuroscience
APOE / Apolipoprotein E Mouse anti-Human Monoclonal (aa100-150) (4E4) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
0.1 ml/$460
APOE / Apolipoprotein E Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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APOE / Apolipoprotein E Mouse anti-Human Monoclonal (aa100-150) (DY650) (4E4) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
DY650 Conjugated
0.1 ml/$416
APOE / Apolipoprotein E Antibody - Anti-APOE / Apolipoprotein E antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Neuroscience
APOE / Apolipoprotein E Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
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APOE / Apolipoprotein E Mouse anti-Human Monoclonal (aa140-160) (8B65) Antibody
Human
ELISA, Flo, IHC, IP, WB
Unconjugated
100 µl/$725
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APOE / Apolipoprotein E Mouse anti-Human Monoclonal (Low Endotoxin) (WUE-4) Antibody
Human
ELISA, WB
Unconjugated, Low Endotoxin
0.5 mg/$697
APOE / Apolipoprotein E Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Neuroscience
APOE / Apolipoprotein E Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC-P
Unconjugated
50 µg/$460
APOE / Apolipoprotein E Antibody - IHC of paraffin-embedded liver cancer tissues (left) and brain tissues (right) using ApoE mouse monoclonal antibody with DAB staining.
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APOE / Apolipoprotein E Mouse anti-Human Monoclonal (1H4) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$459
APOE / Apolipoprotein E Antibody - Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with APOE antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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APOE / Apolipoprotein E Rabbit anti-Human Polyclonal (aa263-292) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
APOE / Apolipoprotein E Antibody - Immunohistochemical analysis of Apolipoprotein E staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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APOE / Apolipoprotein E Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$299
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APOE / Apolipoprotein E Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$891
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APOE / Apolipoprotein E Mouse anti-Human Monoclonal (E3) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$804
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APOE / Apolipoprotein E Mouse anti-Human Monoclonal (WUE-4) Antibody
Human
ELISA, WB
Unconjugated
0.1 mg/$486; 0.2 mg/$556
Viewing 1-25 of 143 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).