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Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
Gene Name: | APH1B gamma secretase subunit |
Synonyms: | APH1B, Aph-1beta, APH-1B, Gamma-secretase subunit APH-1B, PRO1328, PSFL, TAAV688 |
Target Sequences: | NM_031301 NP_112591.2 Q8WW43 |
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