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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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APH1A / APH-1

APH1A gamma secretase subunit

APH1A / APH-1 is a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants.

Gene Name: APH1A gamma secretase subunit
Family/Subfamily: Protease Regulation
Synonyms: APH1A, Aph-1alpha, APH-1, CGI-78, PSF, APH-1A, Gamma-secretase subunit APH-1A
Target Sequences: NM_016022 NP_057106.2 Q96BI3

Viewing 1-25 of 31 items
APH1A / APH-1 Antibody - Anti-APH1A antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Goat Polyclonal to Human APH1A / APH-1
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
APH1A / APH-1 Antibody - Anti-APH1A antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Rabbit Polyclonal (IgG) to Human APH1A / APH-1
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $545.00
APH1A / APH-1 Antibody - Anti-APH1A antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Rabbit Polyclonal (IgG) to Human APH1A / APH-1
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $425.00
Select
Rabbit Polyclonal (IgG) to Human APH1A / APH-1
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal (IgG) to Human APH1A / APH-1
Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human APH1A / APH-1
Human
ELISA, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human APH1A / APH-1
Human
ELISA, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human APH1A / APH-1
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human APH1A / APH-1
Human
ELISA, IHC, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human APH1A / APH-1
Human
ELISA, IHC, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human APH1A / APH-1
Human
ELISA, IHC, WB
AP Conjugated
200µl   $740.00
APH1A / APH-1 Antibody - Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with APH1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Rabbit Polyclonal to Human APH1A / APH-1
Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
APH1A / APH-1 Antibody - Immunofluorescent analysis of Hela cells diluted at 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Rabbit Polyclonal (IgG) to Human APH1A / APH-1
Human
ELISA, IF
Unconjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human APH1A / APH-1
Human
ELISA, WB
Unconjugated
100µg   $405.00
Select
Rabbit Polyclonal (IgG) to Human APH1A / APH-1
Mouse, Human
ELISA, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human APH1A / APH-1
Mouse, Human
ELISA, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human APH1A / APH-1
Mouse, Human
ELISA, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human APH1A / APH-1
Mouse, Human
ELISA, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human APH1A / APH-1
Mouse, Human
ELISA, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human APH1A / APH-1
Mouse, Human
ELISA, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human APH1A / APH-1
Mouse, Human
ELISA, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human APH1A / APH-1
Human
WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
APH1A / APH-1 Antibody - APH1A Antibody western blot of mouse liver tissue lysates (35 ug/lane). The APH1A antibody detected the APH1A protein (arrow).
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Rabbit Polyclonal to Human APH1A / APH-1
Mouse, Human
WB
Unconjugated
400µl   $325.00
APH1A / APH-1 Antibody - APH1a antibody Western blot. All lanes: Anti APH1a at 0.5 ug/ml. Lane 1: Mouse Lung Tissue Lysate at 50 ug. Lane 2: Mouse Liver Tissue Lysate at 50 ug. Lane 3: SW620 Whole Cell Lysate at 40 ug. Lane 4: SMMC Whole Cell Lysate at 40 ug. Lane 5: Human Placenta Tissue Lysate at 50 ug. Predicted band size: 29 kD. Observed band size: 29 kD.
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Rabbit Polyclonal to Human APH1A / APH-1
Mouse, Human
WB
Unconjugated
100µg   $325.00
APH1A / APH-1 Antibody - Western blot analysis of extracts of various cell lines, using APH1A antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 10s.
Select
Rabbit Polyclonal (IgG) to Human APH1A / APH-1
Human
WB
Unconjugated
50µl   $235.00; 100µl   $295.00; 200µl   $385.00

Viewing 1-25 of 31 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).