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Apelin

Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior.

Gene Name: Apelin
Synonyms: APLN, AGTRL1 ligand, Apelin, APEL, Preproapelin, APJ endogenous ligand, XNPEP2
Target Sequences: NM_017413 NP_059109.3 Q9ULZ1

Publications (1)

1
Apelin-13 in septic shock: effective in supporting hemodynamics in sheep but compromised by enzymatic breakdown in patients. David Coquerel , Julie Lamoureux , Frédéric Chagnon , Kien Trn , Michael Sage, Etienne Fortin-Pellerin , Eugénie Delile , Xavier Sainsily , Justin Fournier , Audrey-Ann Dumont, Mannix Auger-Messier , Philippe Sarret , Eric Marsault , Jean-Paul Praud , Tamàs Fülöp, Olivier Lesur. Scientific reports. 2021 Nov;11:22770. [Full Text Article] [PubMed:34815457] [PMC:PMC8611018]

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Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
Apelin (8)
No (8)
GST (2)
His (1)
His-GST (1)
His-MBP (1)
His-S (1)
Myc-DDK (Flag) (2)
Human (5)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (4)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (2)
Apelin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
8.57 kDa
20 µg/$150
Apelin Protein - 12.5% SDS-PAGE of human APLN stained with Coomassie Blue
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Wheat Germ Extract
GST
34.1 kDa
2 µg/$439
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Wheat Germ Extract
GST
39.16 kDa
2 µg/$439
Apelin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
8.57 kDa
100 µg/$494
Apelin Protein - Recombinant Apelin By SDS-PAGE
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E. coli
His
7.6 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
Apelin Protein - Recombinant Apelin By SDS-PAGE
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E. coli
His-MBP
52.7 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
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E. coli
His-S
12.3 kDa
10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136
Apelin Protein - Recombinant Apelin By SDS-PAGE
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E. coli
His-GST
38.6 kDa
10 µg/$282; 50 µg/$447; 100 µg/$715; 200 µg/$892; 1 mg/$2,005; 500 µg/$1,543; 5 mg/$3,123; 2 mg/$2,192
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).