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APAF1 / APAF-1

apoptotic peptidase activating factor 1

Apaf1 has been described as the core of the apoptosome. Deficiency in murine Apaf1 leads to embryonic lethality with a phenotype affecting many aspects of developmental apoptosis. In the developing brain, Apaf1 is a death regulator of the neuronal founder cells. Combined intercrosses of mouse lines mutant for members of the mitochondrial death pathway are providing us with some clues about the relative regulation existing among neuronal cell populations. Apaf1-deficient embryos display an interesting phenotype in the inner ear and in limb development, which involves different caspase-dependent and -independent pathways. Moreover, APAF1 is mutated in human melanomas, and its depletion contributes to malignant transformation in a mouse model of cancer.

Gene Name: apoptotic peptidase activating factor 1
Family/Subfamily: Apoptosis , Not assigned-Other
Synonyms: APAF1, APAF-1, CED4, KIAA0413
Target Sequences: NM_013229 NP_037361.1 O14727

Publications (1)

1
Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload. da Silva VK, de Freitas BS, Garcia RCL, Monteiro RT, Hallak JE, Zuardi AW, Crippa JAS, Schröder N. Translational psychiatry. 2018 September;8:176. [Full Text Article] [PubMed:30177808] [PMC:PMC6120904]

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Products
ELISA Kits (23)
Cell-Based (1)
Custom (3)
Sandwich (14)
Sandwich CLIA (5)
APAF1 / APAF-1 (23)
Human (8)
Mouse (6)
Rat (4)
Chicken (1)
Dog (1)
Monkey (1)
Porcine (1)
Rabbit (1)
12 x 8-Well Microstrips (2)
96-Well Microplate (3)
96-Well Strip Plate (18)
No (22)
Yes (1)
Adherent Cell Cultures (1)
Cell Lysates (3)
Plasma (9)
Serum (9)
Tissue Homogenates (9)
APAF1 / APAF-1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$750
APAF1 / APAF-1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
APAF1 / APAF-1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
APAF1 / APAF-1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
APAF1 / APAF-1 ELISA Kit
Select
Cell-Based
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
APAF1 / APAF-1 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
APAF1 / APAF-1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
APAF1 / APAF-1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
APAF1 / APAF-1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
APAF1 / APAF-1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
APAF1 / APAF-1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
7.81 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$715
APAF1 / APAF-1 ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
APAF1 / APAF-1 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Human
13.72 - 10000 pg/ml
Chemiluminescent
Tissue Homogenates
1 Plate/$851
APAF1 / APAF-1 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Mouse
13.72 - 10000 pg/ml
Chemiluminescent
Tissue Homogenates
1 Plate/$871
APAF1 / APAF-1 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Rat
13.72 - 10000 pg/ml
Chemiluminescent
Tissue Homogenates
1 Plate/$911
APAF1 / APAF-1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
APAF1 / APAF-1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
APAF1 / APAF-1 ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$669
APAF1 / APAF-1 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
APAF1 / APAF-1 ELISA Kit
Select
Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$783
APAF1 / APAF-1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
APAF1 / APAF-1 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
6.25 - 400 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
APAF1 / APAF-1 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
Viewing 1-23 of 23 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).