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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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AP2A2

adaptor-related protein complex 2, alpha 2 subunit

Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.

Gene Name: adaptor-related protein complex 2, alpha 2 subunit
Synonyms: AP2A2, Adaptin, alpha B, ADTAB, Alpha-adaptin C, AP-2 complex subunit alpha-2, CLAPA2, DKFZP564D1864, HIP-9, HIP9, Huntingtin yeast partner J, HYPJ, KIAA0899, Alpha2-adaptin
Target Sequences: NM_012305 NP_036437.1 O94973


☰ Filters
AP2A2 Antibody - Immunohistochemical analysis of AP2-alpha-2 staining in human liver cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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Rabbit Polyclonal to Human AP2A2
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $255.00; 100µl   1mg/ml   $295.00; 200µl   1mg/ml   $375.00
AP2A2 Antibody - Formalin-fixed and paraffin-embedded human hepatocarcinoma with AP2A2 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Rabbit Polyclonal to Human AP2A2
Human
Flo, IHC, IHC-P, WB
Unconjugated
400µl   $325.00
AP2A2 Antibody - Immunohistochemistry of paraffin-embedded human heart tissue at dilution 1:100
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Rabbit Polyclonal (IgG) to Human AP2A2
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   $235.00; 100µl   $285.00
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Rabbit Polyclonal (IgG) to Human AP2A2
Human
ELISA, IHC, WB
Unconjugated
100µg   $435.00
AP2A2 Antibody - 1:100 staining human liver carcinoma tissues by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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Rabbit Polyclonal (IgG) to Human AP2A2
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal to Human AP2A2
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl   1mg/ml   $385.00
AP2A2 Antibody - Immunohistochemistry of paraffin-embedded human liver cancer tissue.
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Rabbit Polyclonal (IgG) to Human AP2A2
Mouse, Human
IHC, WB
Unconjugated
20µl   $215.00; 50µl   $235.00; 100µl   $315.00; 200µl   $425.00
AP2A2 Antibody - Immunohistochemistry of paraffin-embedded human liver cancer using AP2A2 antibody at dilution of 1:200 (40x lens).
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Rabbit Polyclonal (IgG) to Human AP2A2
Mouse, Human
IHC, WB
Unconjugated
20µl   $215.00; 50µl   $235.00; 100µl   $295.00; 200µl   $385.00
Select
Rabbit Polyclonal (IgG) to Human AP2A2
Human
ELISA, WB
Unconjugated
200µl   $590.00
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Rabbit Polyclonal (IgG) to Human AP2A2
Human
ELISA, WB
Biotin Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human AP2A2
Human
ELISA, WB
FITC Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human AP2A2
Human
ELISA, WB
APC Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human AP2A2
Human
ELISA, WB
PE Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human AP2A2
Human
ELISA, WB
HRP Conjugated, Azide-free
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human AP2A2
Human
ELISA, WB
AP Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human AP2A2
Human
IHC-P, WB
Unconjugated
50µl   $365.00
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Rabbit Polyclonal (IgG) to Human AP2A2
Mouse, Human
WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
AP2A2 Antibody - AP2A2 antibody Western blot of Fetal Lung lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human AP2A2
Mouse, Dog, Guinea pig, Rat, Human
WB
Unconjugated
100µl   0.5mg/ml   $365.00
AP2A2 Antibody - AP2A2 antibody Western blot of Fetal Lung lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human AP2A2
Mouse, Dog, Guinea pig, Rat, Human
WB
HRP Conjugated
100µl   0.65mg/ml   $385.00
AP2A2 Antibody - AP2A2 antibody Western blot of Fetal Lung lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human AP2A2
Mouse, Dog, Guinea pig, Rat, Human
WB
Biotin Conjugated
100µl   1mg/ml   $385.00
AP2A2 Antibody - AP2A2 antibody Western blot of Fetal Lung lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human AP2A2
Mouse, Dog, Guinea pig, Rat, Human
WB
FITC Conjugated
100µl   1mg/ml   $385.00
AP2A2 Antibody - Anti-AP2A2 rabbit polyclonal antibody at 1:500 dilution. Lane A: HepG2 Whole Cell Lysate. Lane B: HeLa Whole Cell Lysate. Lane C: Jurkat Whole Cell Lysate. Lane D: A431 Whole Cell Lysate. Lysates/proteins at 30 ug per lane. Secondary: Goat Anti-Rabbit IgG H&L (Dylight 800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 104 kDa. Observed band size: 120 kDa.
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Rabbit Polyclonal (IgG) to Human AP2A2
Human
WB
Unconjugated, Preservative Free
50µl   $235.00; 100µl   $275.00; 200µl   $305.00
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).