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ANK2 / Ankyrin B
ankyrin 2, neuronal
In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions (By similarity). Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner segment of rod photoreceptors. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate.
| Gene Name: | ankyrin 2, neuronal |
| Synonyms: | ANK2, Ankyrin 2, neuronal, Ankyrin, brain, Ankyrin, brain variant 2, ANK-2, Ankyrin B, Ankyrin-2, Ankyrin-2, nonerythrocytic, Ankyrin-B, Brain ankyrin, Brank-2, LQT4, Non-erythroid ankyrin |
| Target Sequences: | NM_001148 NP_001139.3 Q01484 |
Publications (1)
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