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ANGPTL4

angiopoietin-like 4

Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.

Gene Name: angiopoietin-like 4
Synonyms: ANGPTL4, Angiopoietin-like 4, Angiopoietin-related protein 4, Angiopoietin-like protein 4, Fasting-induced adipose factor, NL2, PGAR, Pp1158, ARP4, FIAF, HFARP
Target Sequences: AF202636 AAG22490.1 Q9BY76

Publications (1)

1
ANGPTL4 Promotes the Proliferation of Papillary Thyroid Cancer via AKT Pathway. Longyan Yang , Yan Wang , Rongxin Sun , Yuanyuan Zhang, Ying Fu, Zhaohui Zheng, Zhili Ji, Dong Zhao. OncoTargets and therapy. 2020 Mar;13:2299-2309. [Full Text Article] [PubMed:32231436] [PMC:PMC7085330] Related Antibodies: LS-C331822.

☰ Filters
Products
Proteins (26)
Over-Expression Lysate (4)
Recombinant (22)
ANGPTL4 (26)
No (26)
6His, C-terminus (4)
6His, N-terminus (1)
DDK (Flag) (2)
DDK (Flag)-His, C-terminus (1)
Fc, C-terminus (3)
GST (1)
GST, N-terminus (2)
His (2)
His-DDK (Flag), N-terminus (1)
His-GST (1)
His-S (2)
His-T7 (1)
Mouse IgG Fc, C-terminus (1)
Myc-DDK (Flag) (4)
Bovine (1)
Cynomolgus (3)
Human (12)
Mouse (5)
Pig (1)
Rat (2)
293T Cells (2)
COS-7 Cells (1)
E. coli (7)
HEK 293 Cells (5)
Human (7)
Human Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (2)
Purified (3)
Low endotoxin level (11)
Biologically active (4)
Select
E. coli
GST, N-terminus
69.9 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
ANGPTL4 Protein - ERK phosphorylation induced by hANGPTL4 in THP-1 cells. THP-1 monocyte cells were serum starved for 16 hours and then stimulated with ANGPTL4 (mouse) (rec.) (500ng/ml) for 1, 2 and 3 hours, respectively. Antibodies against pERK1/2 and total ERK1/2 were used for immunoblotting.
Select
COS-7 Cells
DDK (Flag)
Less than 0.1 EU/µg protein (determined by LAL method).
~50kDa (SDS-PAGE)
50 µg/$431; 10 µg/$323
ANGPTL4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
42.9 kDa
20 µg/$150
ANGPTL4 Protein - Recombinant Cynomolgus FGL1 (C-6His)
Select
Human
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
34.8 kDa
10 µg/$301; 50 µg/$478
ANGPTL4 Protein - Recombinant Cynomolgus Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33L3 (C-6His)
Select
Human
6His, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
27.1 kDa
10 µg/$290; 50 µg/$446
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
54.6 kDa
10 µg/$368; 50 µg/$479
ANGPTL4 Protein - 12.5% SDS-PAGE of human ANGPTL4 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
67.65 kDa
2 µg/$439
ANGPTL4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
40.92 kDa
20 µg/$150
ANGPTL4 Protein - Recombinant Mouse Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33L3 (C-6His)
Select
Human
6His, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
26.5 kDa
10 µg/$290; 50 µg/$446
ANGPTL4 Protein - Recombinant Cynomolgus GITR Ligand/TNFSF18 (C-6His)
Select
Human
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
15.3 kDa
10 µg/$290; 50 µg/$446
ANGPTL4 Protein
Select
HEK 293 Cells
DDK (Flag)-His, C-terminus
18 kDa
20 µg/$1,107
ANGPTL4 Protein
Select
HEK 293 Cells
His-DDK (Flag), N-terminus
32 kDa
20 µg/$1,107
ANGPTL4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
40.92 kDa
100 µg/$494
Select
Human
Mouse IgG Fc, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
52.1 kDa
10 µg/$290; 50 µg/$446
Select
Human
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
27.9 kDa
10 µg/$266; 50 µg/$377
ANGPTL4 Protein - Recombinant Human Sialic acid-binding Ig-like lectin 15/Siglec-15/CD33L3 (C-Fc)
Select
Human
Fc, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
53.5 kDa
10 µg/$290; 50 µg/$446
ANGPTL4 Protein - Recombinant Angiopoietin Like Protein 4 By SDS-PAGE
Select
E. coli
His-T7
22.1 kDa
10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796
ANGPTL4 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ANGPTL4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
42.9 kDa
100 µg/$494
Select
HEK 293 Cells
DDK (Flag)
Less than 0.1 EU/µg protein (determined by LAL method).
~35kDa (SDS-PAGE)
50 µg/$793; 10 µg/$379
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
54.6kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
ANGPTL4 Protein - Recombinant Angiopoietin Like Protein 4 By SDS-PAGE
Select
E. coli
His-GST
55.5 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
ANGPTL4 Protein
Select
E. coli
His
15.5 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
ANGPTL4 Protein - Recombinant Angiopoietin Like Protein 4 By SDS-PAGE
Select
E. coli
His-S
30.5 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
ANGPTL4 Protein - Recombinant Angiopoietin Like Protein 4 By SDS-PAGE
Select
E. coli
His-S
29.8 kDa
10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796
Viewing 1-25 of 26 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).