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ANAPC5 / APC5
anaphase promoting complex subunit 5
ANAPC5 / APC5 is a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a.
| Gene Name: | anaphase promoting complex subunit 5 |
| Synonyms: | ANAPC5, Cyclosome subunit 5, APC5 |
| Target Sequences: | NM_016237 NP_057321.2 Q9UJX4 |
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