Products
Research Areas
COVID-19
Resources
Contact Us
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Cart
How To Buy
Contact Us

Locations

Orders Processing,
Shipping & Receiving,
Warehouse

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464

Production Lab

Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036

Telephone Numbers


Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

Contact Us


Additional Contact Details

Distributors
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

AML1 / RUNX1

runt-related transcription factor 1

CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation.

Gene Name: runt-related transcription factor 1
Synonyms: RUNX1, AMLCR1, Aml1 oncogene, AML1, AML1-EVI-1, CBF-alpha-2, CBFA2, Acute myeloid leukemia 1, EVI-1, PEBP2A2, PEA2-alpha B, AML1-EVI-1 fusion protein, Oncogene AML-1, PEBP2-alpha B, PEBP2aB
Target Sequences: NM_001754 NP_001745.2 Q01196

Publications (7)

1
TNF-a signaling regulates RUNX1 function in endothelial cells. Hannah A B Whitmore, Dhanesh Amarnani, Michael O'Hare, Santiago Delgado-Tirado, Lucia Gonzalez-Buendia, Miranda An, Julien Pedron, John H Bushweller, Joseph F Arboleda-Velasquez, Leo A Kim. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 November; [Full Text Article] [PubMed:33135824] [PMC:PMC7821222] Related Antibodies: LS-B13948.
2
Topical delivery of a small molecule RUNX1 transcription factor inhibitor for the treatment of proliferative vitreoretinopathy. Santiago Delgado-Tirado, Dhanesh Amarnani, Guannan Zhao, Elizabeth J Rossin, Dean Eliott, John B Miller, Whitney A Greene, Leslie Ramos, Said Arevalo-Alquichire, David Leyton-Cifuentes, Lucia Gonzalez-Buendia, Daniela Isaacs-Bernal, Hannah A B Whitmore, Natalia Chmielewska, Brandon V Duffy, Eric Kim, Heuy-Ching Wang, Jose M Ruiz-Moreno, Leo A Kim, Joseph F Arboleda-Velasquez. Scientific reports. 2020 November;10:20554. [Full Text Article] [PubMed:33257736] [PMC:PMC7705016] Related Antibodies: LS-B13948.
3
Clinicopathological Significance of RUNX1 in Non-Small Cell Lung Cancer. Yujin Kim, Bo Bin Lee, Dongho Kim, Sangwon Um, Eun Yoon Cho, Joungho Han, Young Mog Shim, Duk-Hwan Kim. Journal of Clinical Medicine. 2020 June;9: [Full Text Article] [PubMed:32498288] [PMC:PMC7356912] Related Antibodies: LS-B5382.
4
Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators. Michael O'Hare, Dhanesh Amarnani, Hannah A B Whitmore, Miranda An, Claudia Marino, Leslie Ramos, Santiago Delgado-Tirado, Xinyao Hu, Natalia Chmielewska, Anita Chandrahas, Antonia Fitzek, Fabian Heinrich, Stefan Steurer, Benjamin Ondruschka, Markus Glatzel, Susanne Krasemann, Diego Sepulveda-Falla, David Lagares, Julien Pedron, John H Bushweller, Paul Liu, Joseph F Arboleda-Velasquez, Leo A Kim. The American journal of pathology. 2021 Jul;;191:1193-1208. [Full Text Article] [PubMed:33894177] [PMC:PMC8059259] Related Antibodies: LS-B13948.
5
Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases. Miran Rada, Audrey Kapelanski-Lamoureux, Stephanie Petrillo, Sébastien Tabariès, Peter Siegel, Andrew R Reynolds, Anthoula Lazaris, Peter Metrakos. Communications biology. 2021 Aug;4:950. [Full Text Article] [PubMed:34376784] [PMC:PMC8355374] Related Antibodies: LS-C353932.
6
Topical Nanoemulsion of a Runt-related Transcription Factor 1 Inhibitor for the Treatment of Pathologic Ocular Angiogenesis. Santiago Delgado-Tirado, Lucia Gonzalez-Buendia, Miranda An, Dhanesh Amarnani, Daniela Isaacs-Bernal, Hannah Whitmore, Said Arevalo-Alquichire, David Leyton-Cifuentes, Jose M Ruiz-Moreno, Joseph F Arboleda-Velasquez, Leo A Kim. Ophthalmology science. 2022 September;2: [Full Text Article] [PubMed:36213726] [PMC:PMC9536424] Related Antibodies: LS-B13948.
7
The molecular mechanisms underlying neutrophil infiltration in vessel co-opting colorectal cancer liver metastases. Miran Rada, Nour Hassan, Anthoula Lazaris, Peter Metrakos. Frontiers in oncology. 2022 November;12:1004793. [Full Text Article] [PubMed:36330498] [PMC:PMC9623070] Related Antibodies: LS-C353932.
more

☰ Filters
Products
Proteins (7)
Over-Expression Lysate (4)
Recombinant (3)
AML1 / RUNX1 (7)
No (7)
GST, N-terminus (1)
His-T7, N-terminus (1)
Myc-DDK (Flag) (5)
Human (5)
293T Cells (2)
E. coli (1)
HEK 293 Cells (3)
Wheat Germ Extract (1)
AML1 / RUNX1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
AML1 / RUNX1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G122732
HEK 293 Cells
Myc-DDK (Flag)
48.6 kDa
100 µg/$710
AML1 / RUNX1 Protein - Purified recombinant protein RUNX1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
Human AML1 / RUNX1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64791
HEK 293 Cells
Myc-DDK (Flag)
48.6 kDa
20 µg/$1,107
AML1 / RUNX1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
AML1 / RUNX1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118416
HEK 293 Cells
Myc-DDK (Flag)
51.6 kDa
100 µg/$710
AML1 / RUNX1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
Human AML1 / RUNX1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74198
293T Cells
Myc-DDK (Flag)
48.6 kDa
20 µg/$215
AML1 / RUNX1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
Human AML1 / RUNX1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74197
293T Cells
Myc-DDK (Flag)
51.6 kDa
20 µg/$215
AML1 / RUNX1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Human AML1 / RUNX1 Protein (Recombinant GST, N-terminus) (aa210-310) - LS-G58002
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
AML1 / RUNX1 Protein - Recombinant Runt Related Transcription Factor 1 (RUNX1) by SDS-PAGE
Select
Human AML1 / RUNX1 Protein (Recombinant His-T7, N-terminus) (Met1-Phe232) - LS-G132587
E. coli
His-T7, N-terminus
29.0kDa
10 µg/$259; 50 µg/$331; 200 µg/$602; 100 µg/$482; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
Viewing 1-7 of 7 product results

(0) Selected Add Selected To Cart Compare Selected Clear Selected Top Of Search
Filtered By:
Products: Proteins


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

Family of Companies
Site Links Home All Antibodies How To Buy All Proteins Distributors All ELISA & Assay Kits Reviews PathPlus™ Antibodies
Follow LSBio View Cart Register or Login
Copyright © 2022 LifeSpan BioSciences, Inc - Privacy Policy
Contact Us

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464

Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

To place an order:
Orders@LSBio.com

For questions about orders:
Customer.Support@LSBio.com

For technical assistance:
Technical.Support@LSBio.com