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ALPL / Alkaline Phosphatase

alkaline phosphatase, liver/bone/kidney

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.

Gene Name: alkaline phosphatase, liver/bone/kidney
Synonyms: ALPL, Alkaline phosphomonoesterase, AP-TNAP, Alkaline phosphatase liver, APTNAP, Glycerophosphatase, Tissue-nonspecific ALP, TNAP, HOPS, Liver alkaline phosphatase, TNSALP
Target Sequences: NM_000478 NP_000469.3 P05186

Publications (1)

1
Collagen-Hydroxyapatite Scaffolds Induce Human Adipose Derived Stem Cells Osteogenic Differentiation In Vitro. Calabrese G, Giuffrida R, Fabbi C, Figallo E, Lo Furno D, Gulino R, Colarossi C, Fullone F, Giuffrida R, Parenti R, Memeo L, Forte S. PloS one. 2016 11:e0151181. (WB, ELISA, IHC-Fr; Bovine, Human) [Full Text Article] [PubMed:26982592] [PMC:PMC4794180] Related Antibodies: LS-C98218.

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ALPL / Alkaline Phosphatase (96)
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ALPL / Alkaline Phosphatase Antibody - Anti-ALPL / Alkaline Phosphatase antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (aa18-502) (2F4) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
50 µg/$460
ALPL / Alkaline Phosphatase Antibody - Anti-Bone Alkaline Phosphatase antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal Antibody
Bovine, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$575
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ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (FITC) Antibody
Bovine, Human
ELISA, WB
FITC Conjugated
100 µl/$951
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ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (TRA-2-49/6E) Antibody
Rabbit, Pig, Cat, Human, Monkey
Flo, IF, IP
Unconjugated
100 µg/$880
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ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (HRP) Antibody
Rabbit, Pig, Cat, Human, Monkey
Flo, ICC, IF, IP
HRP Conjugated
100 µl/$1,094
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ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (Biotin) Antibody
Rabbit, Pig, Cat, Human, Monkey
Flo, ICC, IF, IP
Biotin Conjugated
100 µl/$1,094
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ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (FITC) Antibody
Rabbit, Pig, Cat, Human, Monkey
Flo, ICC, IF, IP
FITC Conjugated
100 µl/$1,094
Select
ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (APC) Antibody
Rabbit, Pig, Cat, Human, Monkey
Flo, ICC, IF, IP
APC Conjugated
100 µl/$1,094
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ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (PE) Antibody
Rabbit, Pig, Cat, Human, Monkey
Flo, ICC, IF, IP
PE Conjugated
100 µl/$1,094
ALPL / Alkaline Phosphatase Antibody - Western blot of ALPL Antibody in MCF-7(lane 1),HL-60 cell line(lane 2) and mouse brain tissue(lane 3) lysates (35 ug/lane). ALPL (arrow) was detected using the purified antibody.
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ALPL / Alkaline Phosphatase Rabbit anti-Human Polyclonal (aa3-32) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
ALPL / Alkaline Phosphatase Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ALPL / Alkaline Phosphatase Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$380
ALPL / Alkaline Phosphatase Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ALPL / Alkaline Phosphatase Rabbit anti-Human Polyclonal (N-Terminus) (Magnetic beads) Antibody
Mouse, Rat, Human
IP
Magnetic beads Conjugated
100 µg/$399
ALPL / Alkaline Phosphatase Antibody - Western Blot analysis of ALPL expression in transfected 293T cell line by ALPL monoclonal antibody (M01), clone 4H1.Lane 1: ALPL transfected lysate(57.3 KDa).Lane 2: Non-transfected lysate.
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ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (4H1) Antibody
Human
ELISA, RNAi, WB
Unconjugated
100 µg/$423
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ALPL / Alkaline Phosphatase Rat anti-Human Monoclonal (aa18-502) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$896
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ALPL / Alkaline Phosphatase Rabbit anti-Human Polyclonal (aa3-32) (PE) Antibody
Mouse, Human
ELISA, WB
PE Conjugated
200 µl/$952
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ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal Antibody
Human
ELISA
Unconjugated
200 µg/$677
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ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
100 µl/$951
ALPL / Alkaline Phosphatase Antibody - Anti-ALPL / Alkaline Phosphatase antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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ALPL / Alkaline Phosphatase Rabbit anti-Human Polyclonal (aa1-359) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
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ALPL / Alkaline Phosphatase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$331
ALPL / Alkaline Phosphatase Antibody - ALPL Antibody in Immunohistochemistry (IHC)
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ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (2F4) Antibody
Human
Flo, IHC, WB
Unconjugated
100 µg/$503
ALPL / Alkaline Phosphatase Antibody - Immunohistochemistry of paraffin-embedded human lung using ALPL / Alkaline Phosphatase antibody at dilution of 1:100.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ALPL / Alkaline Phosphatase Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
ALPL / Alkaline Phosphatase Antibody - Immunohistochemistry of paraffin-embedded human lung using ALPL / Alkaline Phosphatase antibody at dilution of 1:100.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ALPL / Alkaline Phosphatase Rabbit anti-Human Polyclonal (aa28-501) (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
ALPL / Alkaline Phosphatase Antibody - Immunohistochemistry of paraffin-embedded human lung using ALPL / Alkaline Phosphatase antibody at dilution of 1:100.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ALPL / Alkaline Phosphatase Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
ALPL / Alkaline Phosphatase Antibody - IHC testing of FFPE human ovarian carcinoma with ALPL antibody (clone V17.1). Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9, for 10-20 min followed by cooling at RT for 20 min.
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ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (V17.1) Antibody
Human
Flo, IF, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
ALPL / Alkaline Phosphatase Antibody - IHC testing of FFPE human ovarian carcinoma with ALPL antibody (clone V17.1). Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9, for 10-20 min followed by cooling at RT for 20 min.
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ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (Azide-free, BSA-free) (V17.1) Antibody
Human
Flo, IF, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
Viewing 1-25 of 96 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).