Alpha SNAP

N-ethylmaleimide-sensitive factor attachment protein, alpha

The 'SNARE hypothesis' is a model explaining the process of docking and fusion of vesicles to their target membranes. According to this model, membrane proteins from the vesicle (v-SNAREs) and proteins from the target membrane (t-SNAREs) govern the specificity of vesicle targeting and docking through mutual recognition. Once the 2 classes of SNAREs bind to each other, they form a complex that recruits the general elements of the fusion apparatus, namely NSF (N-ethylmaleimide-sensitive factor) and SNAPs (soluble NSF-attachment proteins), to the site of membrane fusion, thereby forming the 20S fusion complex. Alpha- and gamma-SNAP are found in a wide range of tissues and act synergistically in intra-Golgi transport. The sequence of the predicted 295-amino acid human protein encoded by NAPA shares 37%, 60%, and 67% identity with the sequences of yeast, Drosophila, and squid alpha-SNAP, respectively. Platelets contain some of the same proteins, including NSF, p115/TAP, alpha-SNAP, gamma-SNAP, and the t-SNAREs syntaxin-2 and syntaxin-4, that are used in many vesicular transport processes in other cell types. Platelet exocytosis uses a molecular mechanism similar to that used by other secretory cells, such as neurons, although the proteins used by the platelet and their modes of regulation may be quite different.

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Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

Alpha SNAP (8)

Publications

No (8)

Tag

6His, N-terminus (2)

GST (1)

His (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (2)

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Human Alpha SNAP Protein (Recombinant GST) (Full Length) - LS-G31321

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

58.08 kDa

Price:

10 µg/$479; 25 µg/$670

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Human Alpha SNAP Protein (Recombinant His-T7) (aa1-295) - LS-G25029

Source:

E. coli

Tag:

His-T7

Molecular Weight:

36.9 kDa

Price:

10 µg/$256; 50 µg/$325; 100 µg/$460; 200 µg/$572; 1 mg/$1,502; 500 µg/$1,113; 5 mg/$2,421; 2 mg/$1,668

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Human Alpha SNAP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74453

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.1 kDa

Price:

20 µg/$150

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Human Alpha SNAP Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64912

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.1 kDa

Price:

20 µg/$1,107

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Alpha SNAP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100141

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.1 kDa

Price:

100 µg/$494

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Human Alpha SNAP Protein (Recombinant His) - LS-G932

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human Alpha SNAP Protein (Recombinant 6His, N-terminus) (Met1-Arg295) - LS-G140477

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

35.4 kDa

Price:

10 µg/$317; 50 µg/$524

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Human Alpha SNAP Protein (Recombinant 6His, N-terminus) (Met1-Arg295) - LS-G38807

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

35.4kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157

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