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ALOX5 / 5-LOX

arachidonate 5-lipoxygenase

ALOX5 / 5-LOX is a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: arachidonate 5-lipoxygenase
Family/Subfamily: Lipoxygenase , Not assigned-Other
Synonyms: ALOX5, 5-lipoxygenase, 5LPG, 5-LO, 5-LOX, Arachidonate 5-lipoxygenase, LOG5, LOX-5, Leukotriene A4 synthase
Target Sequences: NM_000698 NP_000689.1 P09917

Publications (1)

1
GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation. Sudipta Das, Marina Miller, Andrew K Beppu, James Mueller, Matthew D McGeough, Christine Vuong, Maya R Karta, Peter Rosenthal, Fazila Chouiali, Taylor A Doherty, Richard C Kurten, Qutayba Hamid, Hal M Hoffman, David H Broide. Proceedings of the National Academy of Sciences of the United States of America. 2016 November;113:13132-13137. [Full Text Article] [PubMed:27799535] [PMC:PMC5135378]

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ELISA Kits (25)
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ALOX5 / 5-LOX (25)
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12 x 8-Well Microstrips (3)
96-Well Microplate (5)
96-Well Strip Plate (17)
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Adherent Cell Cultures (2)
Cell Culture Supernatants (1)
Cell Lysates (4)
Plasma (15)
Serum (15)
Tissue Homogenates (8)
ALOX5 / 5-LOX ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
ALOX5 / 5-LOX ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
ALOX5 / 5-LOX ELISA Kit
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Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
ALOX5 / 5-LOX ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$856
ALOX5 / 5-LOX ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
ALOX5 / 5-LOX ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
ALOX5 / 5-LOX ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
ALOX5 / 5-LOX ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Cell Lysates, Tissue Homogenates
1 Plate/$728
ALOX5 / 5-LOX ELISA Kit
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Sandwich
96-Well Microplate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
ALOX5 / 5-LOX ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Rat
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
ALOX5 / 5-LOX ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
ALOX5 / 5-LOX ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
ALOX5 / 5-LOX ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
ALOX5 / 5-LOX ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
ALOX5 / 5-LOX ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Human
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
ALOX5 / 5-LOX ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
ALOX5 / 5-LOX ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
ALOX5 / 5-LOX ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ALOX5 / 5-LOX ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ALOX5 / 5-LOX ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ALOX5 / 5-LOX ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$1,041
ALOX5 / 5-LOX ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$818
ALOX5 / 5-LOX ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
ALOX5 / 5-LOX ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
ALOX5 / 5-LOX ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).