ALOX12 / 12 Lipoxygenase

arachidonate 12-lipoxygenase

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation.

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Products

ELISA Kits (8)

Type

Custom (2)

Sandwich (5)

Sandwich CLIA (1)

Target

ALOX12 / 12 Lipoxygenase (8)

Reactivity

Human (7)

Mouse (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (1)

96-Well Strip Plate (6)

Publications

No (8)

Sample Type

Cell Culture Supernatants (1)

Cell Lysates (2)

Plasma (4)

Serum (4)

Tissue Homogenates (4)

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Mouse ALOX12 / 12 Lipoxygenase (Custom ELISA) ELISA Kit - LS-F18911

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Human ALOX12 / 12 Lipoxygenase (Custom ELISA) ELISA Kit - LS-F18912

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Human ALOX12 / 12 Lipoxygenase (Sandwich ELISA) ELISA Kit - LS-F22205

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Human ALOX12 / 12 Lipoxygenase (CLIA) ELISA Kit - LS-F30387

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$728

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Human ALOX12 / 12 Lipoxygenase (Sandwich ELISA) ELISA Kit - LS-F27054

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

2.5 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

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Human ALOX12 / 12 Lipoxygenase (Sandwich ELISA) ELISA Kit - LS-F36590

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human ALOX12 / 12 Lipoxygenase (Sandwich ELISA) ELISA Kit - LS-F51449

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1.25 - 80 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$1,041

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Human ALOX12 / 12 Lipoxygenase (Sandwich ELISA) ELISA Kit - LS-F9553

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

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