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ALKBH1 / ALKB
alkB, alkylation repair homolog 1 (E. coli)
Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron.
| Gene Name: | alkB, alkylation repair homolog 1 (E. coli) |
| Synonyms: | ALKBH1, ABH, ABH1, ALKBH, Alkb protein homolog, HABH, AlkB, DNA lyase ABH1 |
| Target Sequences: | NM_006020 NP_006011.2 Q13686 |
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