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AKR1B10

aldo-keto reductase family 1, member B10 (aldose reductase)

Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.

Gene Name: aldo-keto reductase family 1, member B10 (aldose reductase)
Synonyms: AKR1B10, AKR1B11, Aldose reductase-like peptide, ALDRLn, AKR1B12, Aldose reductase-like, Aldose reductase-like 1, ARP, HARP, HSI, Small intestine reductase, ARL-1, SI reductase
Target Sequences: NM_020299 NP_064695.3 O60218

Publications (6)

1
Aldo-keto reductase family 1 B10 gene silencing results in growth inhibition of colorectal cancer cells: Implication for cancer intervention. Yan R, Zu X, Ma J, Liu Z, Adeyanju M, Cao D. International journal of cancer. Journal international du cancer. 2007 121:2301-6. [PubMed:17597105]
2
Aldo-keto reductase family 1 B10 affects fatty acid synthesis by regulating the stability of acetyl-CoA carboxylase-alpha in breast cancer cells. Ma J, Yan R, Zu X, Cheng JM, Rao K, Liao DF, Cao D. The Journal of biological chemistry. 2008 283:3418-23. [PubMed:18056116]
3
Oxidation of PAH trans-dihydrodiols by human aldo-keto reductase AKR1B10. Quinn AM, Harvey RG, Penning TM. Chemical research in toxicology. 2008 21:2207-15. [PubMed:18788756] [PMC:PMC2645959]
4
Aldo-keto reductase family 1 member B10 promotes cell survival by regulating lipid synthesis and eliminating carbonyls. Wang C, Yan R, Luo D, Watabe K, Liao DF, Cao D. The Journal of biological chemistry. 2009 284:26742-8. [PubMed:19643728] [PMC:PMC2785362]
5
Gene expression profiling unravels cancer-related hepatic molecular signatures in steatohepatitis but not in steatosis. Starmann J, Flth M, Spindelbck W, Lanz KL, Lackner C, Zatloukal K, Trauner M, Sltmann H. PloS one. 2012 7:e46584. (IHC; Human) [PubMed:23071592] [PMC:PMC3468618]
6
Aldoketoreductase family 1B10 (AKR1B10) as a biomarker to distinguish hepatocellular carcinoma from benign liver lesions. Matkowskyj KA, Bai H, Liao J, Zhang W, Li H, Rao S, Omary R, Yang GY. Human pathology. 2014 45:834-43. (ICC; Human) [Full Text Article] [PubMed:24656094] [PMC:PMC4030546]
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Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
AKR1B10 (7)
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GST (1)
GST, N-terminus (2)
Myc-DDK (Flag) (3)
Human (6)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
Biologically active (1)
AKR1B10 Protein
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E. coli
None
Biologically active
100 µg/$361; 500 µg/$739; 20 µg/$261
AKR1B10 Protein - 12.5% SDS-PAGE of human AKR1B10 stained with Coomassie Blue
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Wheat Germ Extract
GST
60.5 kDa
10 µg/$479; 25 µg/$670
AKR1B10 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
AKR1B10 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
AKR1B10 Protein - Purified recombinant protein AKR1B10 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
35.8 kDa
20 µg/$1,107
AKR1B10 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
35.8 kDa
20 µg/$150
AKR1B10 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
35.8 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).