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AKR1B10

aldo-keto reductase family 1, member B10 (aldose reductase)

Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.

Gene Name: aldo-keto reductase family 1, member B10 (aldose reductase)
Synonyms: AKR1B10, AKR1B11, Aldose reductase-like peptide, ALDRLn, AKR1B12, Aldose reductase-like, Aldose reductase-like 1, ARP, HARP, HSI, Small intestine reductase, ARL-1, SI reductase
Target Sequences: NM_020299 NP_064695.3 O60218

Publications (6)

1
Aldo-keto reductase family 1 B10 gene silencing results in growth inhibition of colorectal cancer cells: Implication for cancer intervention. Yan R, Zu X, Ma J, Liu Z, Adeyanju M, Cao D. International journal of cancer. Journal international du cancer. 2007 121:2301-6. [PubMed:17597105]
2
Aldo-keto reductase family 1 B10 affects fatty acid synthesis by regulating the stability of acetyl-CoA carboxylase-alpha in breast cancer cells. Ma J, Yan R, Zu X, Cheng JM, Rao K, Liao DF, Cao D. The Journal of biological chemistry. 2008 283:3418-23. [PubMed:18056116]
3
Oxidation of PAH trans-dihydrodiols by human aldo-keto reductase AKR1B10. Quinn AM, Harvey RG, Penning TM. Chemical research in toxicology. 2008 21:2207-15. [PubMed:18788756] [PMC:PMC2645959]
4
Aldo-keto reductase family 1 member B10 promotes cell survival by regulating lipid synthesis and eliminating carbonyls. Wang C, Yan R, Luo D, Watabe K, Liao DF, Cao D. The Journal of biological chemistry. 2009 284:26742-8. [PubMed:19643728] [PMC:PMC2785362]
5
Gene expression profiling unravels cancer-related hepatic molecular signatures in steatohepatitis but not in steatosis. Starmann J, Flth M, Spindelbck W, Lanz KL, Lackner C, Zatloukal K, Trauner M, Sltmann H. PloS one. 2012 7:e46584. (IHC; Human) [PubMed:23071592] [PMC:PMC3468618]
6
Aldoketoreductase family 1B10 (AKR1B10) as a biomarker to distinguish hepatocellular carcinoma from benign liver lesions. Matkowskyj KA, Bai H, Liao J, Zhang W, Li H, Rao S, Omary R, Yang GY. Human pathology. 2014 45:834-43. (ICC; Human) [Full Text Article] [PubMed:24656094] [PMC:PMC4030546]
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AKR1B10 ELISA Kit
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Sandwich
96-Well Microplate
Human
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
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1 Plate/$651
AKR1B10 ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
AKR1B10 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$958
AKR1B10 ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).