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AGER / RAGE

advanced glycosylation end product-specific receptor

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.

Gene Name: advanced glycosylation end product-specific receptor
Synonyms: AGER, RAGE, RAGE isoform NtRAGE-delta, RAGE isoform sRAGE-delta
Target Sequences: NM_001136 NP_001127.1 Q15109

Publications (5)

1
Effects of scavenger receptors-1 class A stimulation on macrophage morphology and highly modified advanced glycation end product-protein phagocytosis. Hamasaki S, Kobori T, Yamazaki Y, Kitaura A, Niwa A, Nishinaka T, Nishibori M, Mori S, Nakao S, Takahashi H. Scientific reports. 2018 April;8:5901. (Human) [Full Text Article] [PubMed:29651042] [PMC:PMC5897562] Related Antibodies: LS-C212626.
2
Expression of the receptor for advanced glycation end products, a target for high mobility group box 1 protein, and its role in chronic recalcitrant rhinosinusitis with nasal polyps. Karolina Dzaman, Miroslaw J Szczepanski, Marta Molinska-Glura, Antoni Krzeski, Mariola Zagor. Archivum immunologiae et therapiae experimentalis. 2015 June;63:223-30. [Full Text Article] [PubMed:25503556] [PMC:PMC4429138] Related Antibodies: LS-C212626.
3
RAGE and HMGB1 Expression in Orbital Tissue Microenvironment in Graves' Ophthalmopathy. Dominika Lacheta, Krzysztof B Poslednik, Katarzyna Czerwaty, Nils Ludwig, Marta Molinska-Glura, Ireneusz Kantor, Anna Jablonska-Pawlak, Piotr Miskiewicz, Alicja Gluszko, Zygmunt Stopa, Jacek Brzost, Miroslaw J Szczepanski. Mediators of inflammation. 2021 March;2021:8891324. [Full Text Article] [PubMed:33776579] [PMC:PMC7979288] Related Antibodies: LS-B6042.
4
Advanced glycation end-products reduce lipopolysaccharide uptake by macrophages. Atsuhiro Kitaura, Takashi Nishinaka, Shinichi Hamasaki, Omer Faruk Hatipoglu, Hidenori Wake, Masahiro Nishibori, Shuji Mori, Shinichi Nakao, Hideo Takahashi. PloS one. 2021 January;16:e0245957. [Full Text Article] [PubMed:33493233] [PMC:PMC7833212] Related Antibodies: LS-C212626.
5
Dapagliflozin attenuates diabetes-induced diastolic dysfunction and cardiac fibrosis by regulating SGK1 signaling. Seul-Gee Lee , Darae Kim , Jung-Jae Lee, Hyun-Ju Lee, Ro-Kyung Moon, Yong-Joon Lee, Seung-Jun Lee, Oh-Hyun Lee, Choongki Kim, Jaewon Oh, Chan Joo Lee, Yong-Ho Lee, Seil Park, Ok-Hee Jeon, Donghoon Choi, Geu-Ru Hong, Jung-Sun Kim. BMC medicine. 2022 September;20:309. [Full Text Article] [PubMed:36068525] [PMC:PMC9450279]
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AGER / RAGE Antibody - Anti-RAGE antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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AGER / RAGE Mouse anti-Human Monoclonal (aa23-405) (1C1) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$485
AGER / RAGE Antibody - Anti-RAGE antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AGER / RAGE Mouse anti-Human Monoclonal (Cy3) ( DD/A11) Antibody
Bovine, Human
ELISA, ICC, IHC, IHC-P, WB
Cy3 Conjugated
50 µg/$485
AGER / RAGE Antibody - Anti-AGER / RAGE antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
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AGER / RAGE Rabbit anti-Human Polyclonal (aa350-400) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
AGER / RAGE Antibody - AGER Antibody IHC of formalin-fixed and paraffin-embedded human lung carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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AGER / RAGE Rabbit anti-Human Polyclonal (aa24-52) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
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AGER / RAGE Rabbit anti-Human Polyclonal (aa24-52) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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AGER / RAGE Rabbit anti-Human Polyclonal (aa24-52) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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AGER / RAGE Rabbit anti-Human Polyclonal (aa24-52) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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AGER / RAGE Rabbit anti-Human Polyclonal (aa24-52) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
AGER / RAGE Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AGER / RAGE Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µg/$380
AGER / RAGE Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AGER / RAGE Rabbit anti-Human Polyclonal (N-Terminus) (Magnetic beads) Antibody
Mouse, Rat, Human
IP
Magnetic beads Conjugated
100 µg/$399
AGER / RAGE Antibody - AGER monoclonal antibody (M02), clone 1C1. Western Blot analysis of AGER expression in human kidney.
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AGER / RAGE Mouse anti-Human Monoclonal (1C1) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$423
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AGER / RAGE Rat anti-Mouse Monoclonal (Extracellular Domain) (175409) Antibody
Mouse
ELISA, WB
Unconjugated
500 µg/$1,089
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AGER / RAGE Mouse anti-Human Monoclonal (FITC) Antibody
Mouse, Bovine, Human
ELISA, ICC, IHC, WB
FITC Conjugated
100 µl/$1,094
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AGER / RAGE Mouse anti-Human Monoclonal (Biotin) Antibody
Mouse, Bovine, Human
ELISA, ICC, IHC, WB
Biotin Conjugated
100 µl/$1,094
AGER / RAGE Antibody - 1:100 staining human urothelial carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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AGER / RAGE Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
AGER / RAGE Antibody - AGER antibody ARP41643_T100-NP_751947-AGER(advanced glycosylation end product-specific receptor) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AGER / RAGE Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
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AGER / RAGE Rabbit anti-Human Polyclonal (aa29-59) Antibody
Human
ELISA, IHC
Unconjugated
200 µl/$734
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AGER / RAGE Sheep anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$628
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AGER / RAGE Mouse anti-Human Monoclonal (Extracellular Domain) (PE) Antibody
Mouse, Bovine, Human
ELISA, ICC, IHC, WB
PE Conjugated
100 µl/$1,094
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AGER / RAGE Mouse anti-Human Monoclonal (Extracellular Domain) (APC) Antibody
Mouse, Bovine, Human
ELISA, ICC, IHC, WB
APC Conjugated
100 µl/$1,094
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AGER / RAGE Mouse anti-Human Monoclonal (HRP) Antibody
Mouse, Bovine, Human
ELISA, ICC, IHC, WB
HRP Conjugated
100 µl/$1,094
AGER / RAGE Antibody - Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AGER / RAGE Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
AGER / RAGE Antibody - Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AGER / RAGE Rabbit anti-Human Polyclonal (aa23-342) (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
AGER / RAGE Antibody - Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AGER / RAGE Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
AGER / RAGE Antibody - Immunohistochemistry of paraffin-embedded Human breast cancer using AGER Polyclonal Antibody at dilution of 1:70.
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AGER / RAGE Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).