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AF5Q31 / AFF4

AF4/FMR2 family, member 4

Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression.

Gene Name: AF4/FMR2 family, member 4
Synonyms: AFF4, AF4/FMR2 family member 4, AF4/FMR2 family, member 4, AF5Q31, MCEF, Protein AF-5q31
Target Sequences: NM_014423 NP_055238.1 Q9UHB7

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).