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Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.
Gene Name: | apoptosis enhancing nuclease |
Synonyms: | AEN, Apoptosis enhancing nuclease, Apoptosis-enhancing nuclease, ISG20L1, Pp12744 |
Target Sequences: | NM_022767 NP_073604.3 Q8WTP8 |
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