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ADM / Adrenomedullin

adrenomedullin

Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element.

Gene Name: adrenomedullin
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: ADM, Adrenomedullin, AM, Preproadrenomedullin
Target Sequences: NM_001124 NP_001115.1 P35318

Publications (2)

1
Suppression of CCL2 angiocrine function by adrenomedullin promotes tumor growth. Akiko Nakayama, Kenneth Anthony Roquid, András Iring, Boris Strilic, Stefan Günther, Min Chen, Lee S Weinstein, Stefan Offermanns. The Journal of experimental medicine. 2023 Janurary;220: [Full Text Article] [PubMed:36374225] [PMC:PMC9665902] Related Antibodies: LS-B15534.
2
Temporal and spatial expression of adrenomedullin and its receptors in the porcine uterus and peri-implantation conceptuses. Sudikshya Paudel, Bangmin Liu, Magdalina J Cummings, Kelsey E Quinn, Fuller W Bazer, Kathleen M Caron, Xiaoqiu Wang. Biology of reproduction. 2021 October;105:876-891. [Full Text Article] [PubMed:34104954] [PMC:PMC8511665]

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Products
Proteins (11)
Over-Expression Lysate (2)
Recombinant (9)
ADM / Adrenomedullin (11)
No (11)
6His, N-terminus (1)
Fc (1)
GST (1)
GST, N-terminus (1)
His (3)
His, N-Terminal (1)
Myc-DDK (Flag) (3)
Bovine (1)
Dog (1)
Human (6)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (5)
HEK 293 Cells (2)
Human Cells (1)
Wheat Germ Extract (2)
Purified (2)
Low endotoxin level (1)
ADM / Adrenomedullin Protein - Recombinant Adrenomedullin By SDS-PAGE
Select
E. coli
6His, N-terminus
15.8 kDa
10 µg/$299; 50 µg/$552; 100 µg/$882; 200 µg/$1,080; 1 mg/$2,261; 500 µg/$1,775; 5 mg/$3,851; 2 mg/$2,453
ADM / Adrenomedullin Protein - Recombinant Adrenomedullin By SDS-PAGE
Select
E. coli
His
19.4 kDa
10 µg/$297; 50 µg/$542; 100 µg/$865; 200 µg/$1,065; 1 mg/$2,239; 500 µg/$1,755; 5 mg/$3,781; 2 mg/$2,430
ADM / Adrenomedullin Protein
Select
E. coli
His, N-Terminal
18.4 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
ADM / Adrenomedullin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
20.2 kDa
100 µg/$494
ADM / Adrenomedullin Protein - 12.5% SDS-PAGE of human ADM stained with Coomassie Blue
Select
Wheat Germ Extract
GST
46.8 kDa
2 µg/$439
Select
293T Cells
Myc-DDK (Flag)
20.2 kDa
20 µg/$150
ADM / Adrenomedullin Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
2 µg/$439
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
38 kDa
50 µg/$721
ADM / Adrenomedullin Protein - Purified recombinant protein ADM was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
20.2 kDa
20 µg/$1,107
ADM / Adrenomedullin Protein - Recombinant Adrenomedullin By SDS-PAGE
Select
E. coli
His
16.8 kDa
10 µg/$300; 50 µg/$562; 100 µg/$897; 200 µg/$1,096; 1 mg/$2,284; 500 µg/$1,796; 5 mg/$3,921; 2 mg/$2,476
ADM / Adrenomedullin Protein - Recombinant Adrenomedullin By SDS-PAGE
Select
E. coli
His
19.2 kDa
10 µg/$304; 50 µg/$587; 100 µg/$940; 200 µg/$1,133; 1 mg/$2,340; 500 µg/$1,848; 5 mg/$4,103; 2 mg/$2,532
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).