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ADGRV1 / GPR98

G protein-coupled receptor 98

Very Large G Protein-Coupled Receptor-1 (VLGR1) is an Orphan-A GPCR with an unknown ligand. VLGR1 consists of three expressed isoforms. VLGR1 has a large ectodomain containing multiple CALX-beta repeats that resemble regulatory domains of sodium-calcium exchanger proteins. VLGR1b, which is the only form expressed in mouse, is apparently the largest known cell-surface protein with an ectodomain containing 35 CALX- repeats and a pentraxin homology domain. The MASS1 gene, which is a fragment of the very large G-protein-coupled receptor VLGR1, is mutated in the Frings mouse model of audiogenic epilepsy.

Gene Name: G protein-coupled receptor 98
Family/Subfamily: GPCR , Orphan-A
Synonyms: ADGRV1, FEB4, KIAA0686, G-protein coupled receptor 98, MASS1, VLGR1b, Usher syndrome type-2C protein, USH2B, USH2C, G protein-coupled receptor 98, GPR98, KIAA1943, VLGR1
Target Sequences: AF435925 AAL30811.1 Q8WXG9

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).