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ADGRE3 / EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
ADGRE3 / EMR3 is a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms.
| Gene Name: | egf-like module containing, mucin-like, hormone receptor-like 3 |
| Family/Subfamily: | GPCR , Orphan-B |
| Synonyms: | ADGRE3, EGF-like module receptor 3, EMR3 |
| Target Sequences: | NM_032571 NP_115960.2 Q9BY15 |
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