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ADAMTS10 belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.
Gene Name: | ADAM metallopeptidase with thrombospondin type 1 motif, 10 |
Family/Subfamily: | Protease , Metallopeptidase M12B |
Synonyms: | ADAMTS10, ADAM-TS 10, ADAM-TS10, ADAMTS-10, Zinc metalloendopeptidase, WMS1, WMS |
Target Sequences: | NM_030957 NP_112219.3 Q9H324 |
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