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ADAM18 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene Name: | ADAM metallopeptidase domain 18 |
Family/Subfamily: | Protease Non Catalytic , Metallopeptidase Non-catalytic |
Synonyms: | ADAM18, ADAM27, ADAM 18, Dtgn3, TMDCIII, TMDC III, Disintegrin 3, TMDC3 |
Target Sequences: | NM_014237 NP_055052.1 Q9Y3Q7 |
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