ADAM10

ADAM metallopeptidase domain 10

Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.

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Products

Proteins (6)

Type

Over-Expression Lysate (3)

Recombinant (3)

Target

ADAM10 (6)

Publications

No (6)

Tag

8His, N-terminus (1)

GST, N-terminus (1)

His (2)

Myc-DDK (Flag) (2)

Species

Human (4)

Rat (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Rat ADAM10 Protein (Recombinant His) (aa218-445) - LS-G12760

Source:

E. coli

Tag:

His

Molecular Weight:

26.5 kDa

Price:

10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257

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Human ADAM10 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88832

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

84 kDa

Price:

20 µg/$215

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ADAM10 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118779

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

84 kDa

Price:

100 µg/$710

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Human ADAM10 Protein (Over-Expression Lysate 8His, N-terminus) (Gly19-Val512) - LS-G26685

Source:

HEK 293 Cells

Tag:

8His, N-terminus

Molecular Weight:

57.5 kDa

Price:

100 µg/$298

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Human ADAM10 Protein (Recombinant GST, N-terminus) (aa346-435) - LS-G57696

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ADAM10 Protein (Recombinant His) (aa420-641) - LS-G12758

Source:

E. coli

Tag:

His

Molecular Weight:

25.7 kDa

Price:

10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198

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