Products
Research Areas
COVID-19
Resources
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us

Locations


Orders Processing,
Shipping & Receiving,
Warehouse

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464


Production Lab

Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036

Telephone Numbers



Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

Contact Us



Additional Contact Details

Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

ACVR1B / ALK4

activin A receptor, type IB

Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.

Gene Name: activin A receptor, type IB
Family/Subfamily: Protein Kinase , Activin/TGFb
Synonyms: ACVR1B, ACTR-IB, ACTRIB, ALK4, Activin receptor type IB, Activin A Receptor Type IB, Activin A receptor, type IB, Activin receptor-like kinase 4, ACVRLK4, ALK-4, Activin receptor type-1B, SKR2-2, SKR2
Target Sequences: NM_004302 NP_004293.1 P36896

Publications (1)

1
The Dynamics of TGF-ß Signaling Are Dictated by Receptor Trafficking via the ESCRT Machinery. Miller DSJ, Bloxham RD, Jiang M, Gori I, Saunders RE, Das D, Chakravarty P, Howell M, Hill CS. Cell reports. 2018 November;25:1841-1855. [Full Text Article] [PubMed:30428352] Related Antibodies: LS-B2695.

☰ Filters
Products
Antibodies (56)
Primary (56)
ACVR1B / ALK4 (56)
Human (41)
Mouse (34)
Rat (8)
Monkey (1)
IHC (5)
IHC-P (3)
WB (50)
Flo (9)
ELISA (26)
IF (6)
Neut (1)
Peptide-ELISA (2)
rabbit (43)
mouse (10)
goat (3)
Product Group
IHCPlus (2)
IgG (21)
IgG1 (1)
IgG1,k (7)
IgG2a,k (1)
IgG2b (1)
monoclonal mc (10)
polyclonal pc (46)
179CT11.2.1 (6)
2D4 (1)
APC (2)
APC Conjugated (4)
Azide-free (2)
Biotin Conjugated (7)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (4)
Unconjugated (27)
aa207-385 (8)
aa24-126 (8)
aa134-164 (7)
Extracellular Domain (4)
50-130 aa, Internal (1)
C-Terminus (1)
Gly111 (1)
Internal (1)
aa154-415 (1)
aa39-68 (1)
aa73-122 (1)
No (55)
Yes (1)
ACVR1B / ALK4 Antibody - Anti-ACVR1 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
ACVR1B / ALK4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
ACVR1B / ALK4 Antibody - Immunofluorescence analysis of HeLa cells, using ACV1B Antibody. The picture on the right is blocked with the synthesized peptide.
Select
ACVR1B / ALK4 Rabbit anti-Human Polyclonal (aa73-122) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
ACVR1B / ALK4 Goat anti-Human Polyclonal (Extracellular Domain) Antibody
Human
ELISA, Neut, WB
Unconjugated
100 µg/$929
ACVR1B / ALK4 Antibody - IHC of ACTR-IB (G111) pAb in paraffin-embedded human brain tissue.
Select
ACVR1B / ALK4 Rabbit anti-Human Polyclonal (Gly111) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
Select
ACVR1B / ALK4 Mouse anti-Human Monoclonal (Extracellular Domain) Antibody
Human
ELISA, Flo
Unconjugated
100 µg/$941
ACVR1B / ALK4 Antibody - The anti-ACVR1B antibody is used in Western blot to detect ACVR1B in mouse kidney tissue lysate.
Select
ACVR1B / ALK4 Rabbit anti-Human Polyclonal (aa39-68) Antibody
Mouse, Rat, Human
Flo, WB
Unconjugated
400 µl/$393
ACVR1B / ALK4 Antibody - The anti-ACVR1B antibody is used in Western blot to detect ACVR1B in Jurkat (1) and mouse kidney (2) tissue lysates.
Select
ACVR1B / ALK4 Rabbit anti-Human Polyclonal (aa134-164) Antibody
Mouse, Human
Flo, WB
Unconjugated
400 µl/$393
ACVR1B / ALK4 Antibody - Western blot of recombinant ACVR1B / ALK4.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
ACVR1B / ALK4 Rabbit anti-Mouse Polyclonal (aa207-385) (PE) Antibody
Mouse
WB
PE Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
ACVR1B / ALK4 Antibody - Western blot of ACTR-IB antibody
Select
ACVR1B / ALK4 Rabbit anti-Human Polyclonal (50-130 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ACVR1B / ALK4 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
ACVR1B / ALK4 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ACVR1B / ALK4 Antibody - Peptide - + Immunofluorescence analysis of HeLa cells, using ACV1B antibody.
Select
ACVR1B / ALK4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100 µg/$357
Select
ACVR1B / ALK4 Rabbit anti-Human Polyclonal (aa134-164) Antibody
Mouse, Human
ELISA, Flo, WB
Unconjugated
200 µl/$734
Select
ACVR1B / ALK4 Rabbit anti-Human Polyclonal (aa134-164) (Biotin) Antibody
Mouse, Human
ELISA, Flo, WB
Biotin Conjugated
200 µl/$952
Select
ACVR1B / ALK4 Rabbit anti-Human Polyclonal (aa134-164) (FITC) Antibody
Mouse, Human
ELISA, Flo, WB
FITC Conjugated
200 µl/$952
Select
ACVR1B / ALK4 Rabbit anti-Human Polyclonal (aa134-164) (PE) Antibody
Mouse, Human
ELISA, Flo, WB
PE Conjugated
200 µl/$952
Select
ACVR1B / ALK4 Rabbit anti-Human Polyclonal (aa134-164) (APC) Antibody
Mouse, Human
ELISA, Flo, WB
APC Conjugated
200 µl/$952
Select
ACVR1B / ALK4 Rabbit anti-Human Polyclonal (aa134-164) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, Flo, WB
HRP Conjugated, Azide-free
200 µl/$952
ACVR1B / ALK4 Antibody - Staining MCF-7 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
Select
ACVR1B / ALK4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
ACVR1B / ALK4 Mouse anti-Mouse Monoclonal (179CT11.2.1) Antibody
Mouse
ELISA, WB
Unconjugated
200 µl/$734
Select
ACVR1B / ALK4 Mouse anti-Mouse Monoclonal (FITC) (179CT11.2.1) Antibody
Mouse
ELISA, WB
FITC Conjugated
200 µl/$952
Select
ACVR1B / ALK4 Mouse anti-Mouse Monoclonal (APC) (179CT11.2.1) Antibody
Mouse
ELISA, WB
APC Conjugated
200 µl/$952
Select
ACVR1B / ALK4 Mouse anti-Mouse Monoclonal (Azide-free) (HRP) (179CT11.2.1) Antibody
Mouse
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
ACVR1B / ALK4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
50 µg/$305; 100 µg/$357
ACVR1B / ALK4 Antibody - Western blot analysis of extracts of various cell lines.
Select
ACVR1B / ALK4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
ACVR1B / ALK4 Antibody - Detection limit for recombinant GST tagged ACVR1B is approximately 0.03 ng/ml as a capture antibody.
Select
ACVR1B / ALK4 Mouse anti-Human Monoclonal (2D4) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
Viewing 1-25 of 56 product results


Filtered By:
Products: Antibodies


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).