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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ACTG1 / Gamma Actin

actin, gamma 1

Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in non-muscle cells. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss. Alternative splicing results in multiple transcript variants.

Gene Name: actin, gamma 1
Synonyms: ACTG1, ACTG, Actin, gamma 1, BRWS2, Cytoskeletal gamma-actin, DFNA20, Actin, cytoplasmic 2, Gamma-actin, DFNA26
Target Sequences: NM_001614 NP_001605.1 P63261

Publications (14)

1
Genome-wide discovery of loci influencing chemotherapy cytotoxicity. Watters JW, Kraja A, Meucci MA, Province MA, McLeod HL. Proceedings of the National Academy of Sciences of the United States of America. 2004 101:11809-14. [PubMed:15282376] [PMC:PMC511056]
2
Localization and role of NPC1L1 in cholesterol absorption in human intestine. San AT, Sinnett D, Delvin E, Bendayan M, Marcil V, Mnard D, Beaulieu JF, Levy E. Journal of lipid research. 2006 47:2112-20. [PubMed:16829661]
3
MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development. Boutz PL, Chawla G, Stoilov P, Black DL. Genes & development. 2007 21:71-84. [PubMed:17210790] [PMC:PMC1759902]
4
Small interfering RNA profiling reveals key role of clathrin-mediated endocytosis and early endosome formation for infection by respiratory syncytial virus. Kolokoltsov AA, Deniger D, Fleming EH, Roberts NJ, Karpilow JM, Davey RA. Journal of virology. 2007 81:7786-800. [PubMed:17494077] [PMC:PMC1933373]
5
Effects of dietary decosahexaenoic acid (DHA) on eNOS in human coronary artery endothelial cells. Stebbins CL, Stice JP, Hart CM, Mbai FN, Knowlton AA. Journal of cardiovascular pharmacology and therapeutics. 2008 13:261-8. [PubMed:18682551]
6
Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling. Goffart S, Cooper HM, Tyynismaa H, Wanrooij S, Suomalainen A, Spelbrink JN. Human molecular genetics. 2009 18:328-40. [PubMed:18971204] [PMC:PMC2638771]
7
Preferential killing of breast tumor initiating cells by N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine/tesmilifene. Deng T, Liu JC, Pritchard KI, Eisen A, Zacksenhaus E. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 15:119-30. [PubMed:19118039]
8
Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells. Ghosh AK, Shanafelt TD, Cimmino A, Taccioli C, Volinia S, Liu CG, Calin GA, Croce CM, Chan DA, Giaccia AJ, Secreto C, Wellik LE, Lee YK, Mukhopadhyay D, Kay NE. Blood. 2009 113:5568-74. [PubMed:19336759] [PMC:PMC2689054]
9
Human Dna2 is a nuclear and mitochondrial DNA maintenance protein. Duxin JP, Dao B, Martinsson P, Rajala N, Guittat L, Campbell JL, Spelbrink JN, Stewart SA. Molecular and cellular biology. 2009 29:4274-82. [PubMed:19487465] [PMC:PMC2715806]
10
Gammaherpesvirus gene expression and DNA synthesis are facilitated by viral protein kinase and histone variant H2AX. Mounce BC, Tsan FC, Droit L, Kohler S, Reitsma JM, Cirillo LA, Tarakanova VL. Virology. 2011 420:73-81. [PubMed:21943826] [PMC:PMC3204369]
11
The human lung adenocarcinoma cell line EKVX produces an infectious xenotropic murine leukemia virus. Cmarik JL, Troxler JA, Hanson CA, Zhang X, Ruscetti SK. Viruses. 2011 3:2442-61. [PubMed:22355448] [PMC:PMC3280514]
12
Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication. Duxin JP, Moore HR, Sidorova J, Karanja K, Honaker Y, Dao B, Piwnica-Worms H, Campbell JL, Monnat RJ, Stewart SA. The Journal of biological chemistry. 2012 287:21980-91. (WB; Human) [PubMed:22570476] [PMC:PMC3381158]
13
Krppel-like factor 10 upregulates the expression of cyclooxygenase 1 and further modulates angiogenesis in endothelial cell and platelet aggregation in gene-deficient mice. Yang DH, Hsu CF, Lin CY, Guo JY, Yu WC, Chang VH. The international journal of biochemistry & cell biology. 2013 45:419-28. (WB; Mouse, Human) [PubMed:23178857]
14
Polarization of membrane associated proteins in the choroid plexus epithelium from normal and slc4a10 knockout mice. Christensen IB, Gyldenholm T, Damkier HH, Praetorius J. Frontiers in physiology. 2013 4:344. (IHC; Mouse) [Full Text Article] [PubMed:24348423] [PMC:PMC3842056] Related Antibodies: LS-C34852.
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Viewing 1-9 of 9 items
ACTG1 / Gamma Actin ELISA Kit
Select
Sandwich
96-Well Microplate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate   $590.00
ACTG1 / Gamma Actin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1plate   $790.00
ACTG1 / Gamma Actin ELISA Kit
Select
Custom
96-Well Strip Plate
Guinea pig
1.563 - 100 pg/ml
Colorimetric - 450nm (TMB)
1plate   $660.00
ACTG1 / Gamma Actin ELISA Kit
Select
Custom
96-Well Strip Plate
Monkey
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1plate   $660.00
ACTG1 / Gamma Actin ELISA Kit
Select
Custom
96-Well Strip Plate
Porcine
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1plate   $660.00
ACTG1 / Gamma Actin ELISA Kit
Select
Custom
96-Well Strip Plate
Chicken
1.563 - 100 pg/ml
Colorimetric - 450nm (TMB)
1plate   $660.00
ACTG1 / Gamma Actin ELISA Kit
Select
Custom
96-Well Strip Plate
Rabbit
1.25 - 80 pg/ml
Colorimetric - 450nm (TMB)
1plate   $660.00
ACTG1 / Gamma Actin ELISA Kit
Select
Custom
96-Well Strip Plate
Sheep
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
1plate   $730.00
ACTG1 / Gamma Actin ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
15.625 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1plate   $700.00

Viewing 1-9 of 9 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).