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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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ACPP / PAP
acid phosphatase, prostate
A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.
| Gene Name: | acid phosphatase, prostate |
| Synonyms: | ACPP, ACP3, 5-NT, 5-nucleotidase, Acid phosphatase, prostate, ACP-3, Ecto-5-nucleotidase, PAP, Prostatic acid phosphatase, Thiamine monophosphatase, Prostatic acid phosphotase, TMPase |
| Target Sequences: | NM_001099 NP_001090.2 P15309 |
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