ACER1 / ASAH3

alkaline ceramidase 1

Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

ACER1 / ASAH3 (3)

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Myc-DDK (Flag) (3)

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Human (2)

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293T Cells (1)

HEK 293 Cells (2)

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ACER1 / ASAH3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107529

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.9 kDa

Price:

100 µg/$494

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Human ACER1 / ASAH3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72655

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.9 kDa

Price:

20 µg/$1,107

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Human ACER1 / ASAH3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G93174

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.9 kDa

Price:

20 µg/$150

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