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ACE2 / ACE-2

angiotensin I converting enzyme 2

Angiotensin-Converting Enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function. ACE2 is also the attachment receptor for HCoV-N63, SARS-CoV and SARS-CoV-2. The S1 portion of the coronavirus spike protein attaches to ACE2 presented on the host cell surface. The SARS-CoV-2 virus targets pneumocytes and macrophages expressing ACE2 in the lung, and it is believed to infect ACE2-positive cells in other tissues including the gastrointestinal tract and potentially the liver (in cholangiocytes).

Gene Name: angiotensin I converting enzyme 2
Family/Subfamily: Protease , Metallopeptidase M2
Synonyms: ACE2, ACE-related carboxypeptidase, ACEH, Metalloprotease MPROT15, SARS-CoV2 Coronavirus Receptor, SARS-CoV-2 Coronavirus Receptor, COVID-19 viral receptor
Target Sequences: NM_021804 NP_068576.1 Q9BYF1

Publications (2)

1
Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms. Adedeji AO, Severson W, Jonsson C, Singh K, Weiss SR, Sarafianos SG. Journal of virology. 2013 87:8017-28. (IHC; Human) [Full Text Article] [PubMed:23678171] [PMC:PMC3700180] Related Antibodies: LS-C122669.
2
Pancreatic angiotensin-converting enzyme 2 improves glycemia in angiotensin II-infused mice. Chhabra KH, Xia H, Pedersen KB, Speth RC, Lazartigues E. American journal of physiology. Endocrinology and metabolism. 2013 Apr;304:E874-84. [Full Text Article] [PubMed:23462816] [PMC:PMC3625779] Related Antibodies: LS-B3197.

☰ Filters
Products
Proteins (22)
Over-Expression Lysate (8)
Recombinant (14)
ACE2 / ACE-2 (22)
WB (8)
Product Group
Coronavirus Antibodies Proteins cDNAs (20)
SARS-CoV-2 Associated Proteins (21)
No (22)
6His, C-terminus (4)
AVI-6His, C-terminus (1)
Fc, C-terminus (1)
Fc/His,C-terminus (1)
His (2)
His,C-terminus (4)
His-T7 (2)
Human Fc, C-terminus (1)
Human IgG Fc, C-terminus (2)
Human IgG1 Fc, C-terminus (2)
mFc, C-terminus (1)
Mouse IgG1 Fc, C-terminus (1)
Coronavirus SARS-CoV-2 (1)
Human (11)
Monkey-Rhesus (2)
Mouse (5)
Rat (3)
E. coli (2)
HEK 293 Cells (11)
Human Cells (8)
Mammalian Cells (1)
Purified (4)
Low endotoxin level (11)
Biologically active (3)
Select
HEK 293 Cells
His,C-terminus
WB
The secreted recombinant mouse ACE2 comprises 734 amino acids and has a predicted molecular mass of 85 kDa. As a result of glycosylation, it migrates as an approximately 110 kDa band in SDS-PAGE under reducing conditions.
300 µg/$305
ACE2 / ACE-2 Protein
Select
HEK 293 Cells
Human Fc, C-terminus
100 µg/$355; 50 µg/$265
Select
HEK 293 Cells
Human IgG Fc, C-terminus
WB
The recombinant human ACE2/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 961 amino acids and predicts a molecular mass of 110.3 kDa. As a result of glycosylation, the rhACE2/Fc monomer migrates as approximately 145-150 kDa band in SDS-PAGE under reducing conditions.
300 µg/$305
ACE2 / ACE-2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
84.63 kDa
1 mg/$2,445; 500 µg/$1,710; 50 µg/$445; 10 µg/$255
Select
Human Cells
Human IgG1 Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
110.3 kDa
10 µg/$485; 20 µg/$815
Select
HEK 293 Cells
Human IgG1 Fc, C-terminus
WB
The secreted recombinant mouse ACE2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 971 amino acids and has a predicted molecular mass of 112 kDa. As a result of glycosylation, it migrates as an approximately 130 kDa band in SDS-PAGE under reducing conditions.
300 µg/$305
Select
HEK 293 Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
84.63 kDa
100 µg/$415
Select
HEK 293 Cells
His,C-terminus
WB
The recombinant human ACE2 consists of 734 amino acids and predicts a molecular mass of 85.1 kDa.
300 µg/$305
Select
HEK 293 Cells
Mouse IgG1 Fc, C-terminus
WB
The recombinant human ACE2 consists 957 amino acids and predicts a molecular mass of 110 kDa.
300 µg/$305
Select
HEK 293 Cells
His,C-terminus
WB
The recombinant rat ACE2 comprises 734 amino acids and predicts a molecular mass of 85 kDa. The apparent molecular mass of the rat ACE2 is approximately 105-115 kDa in SDS-PAGE under reducing conditions.
300 µg/$305
Select
HEK 293 Cells
Human IgG Fc, C-terminus
WB
The recombinant Rhesus ACE2 is a disulfide-linked homodimer. The reduced monomer comprises 963 amino acids and has a calculated molecular mass of 110.7 kDa.The apparent molecular mass of the protein is approximately 112 kDa respectively in SDS-PAGE.
300 µg/$305
Select
HEK 293 Cells
His,C-terminus
WB
The recombinant Rhesus ACE2 comprises 733 amino acids and has a calculated molecular mass of 85.1 kDa. The apparent molecular mass of it is approximately 108 and 66 kDa in SDS-PAGE under reducing conditions.
300 µg/$305
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
84.63kD
10 µg/$265; 50 µg/$465; 500 µg/$1,605; 1 mg/$2,310
ACE2 / ACE-2 Protein - Recombinant Angiotensin I Converting Enzyme 2 By SDS-PAGE
Select
E. coli
His-T7
46.6 kDa
50 µg/$485; 10 µg/$285; 200 µg/$965; 100 µg/$650; 1 mg/$2,460
ACE2 / ACE-2 Protein - Recombinant Angiotensin I Converting Enzyme 2 By SDS-PAGE
Select
E. coli
His-T7
43.8 kDa
50 µg/$495; 10 µg/$295; 200 µg/$995; 100 µg/$680; 1 mg/$2,580
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
84.6 kDa
10 µg/$355; 50 µg/$590
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
85 kDa
10 µg/$485; 20 µg/$815
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
85 kDa
10 µg/$485; 20 µg/$815
Select
HEK 293 Cells
Fc/His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
112 kDa
10 µg/$435; 20 µg/$650
ACE2 / ACE-2 Protein
Select
Human Cells
mFc, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
110 kDa
10 µg/$255; 50 µg/$445
ACE2 / ACE-2 Protein
Select
Human Cells
AVI-6His, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
86.2 kDa
20 µg/$365; 100 µg/$830
ACE2 / ACE-2 Protein
Select
Human Cells
Fc, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
110.5 kDa
10 µg/$255; 50 µg/$445
Viewing 1-22 of 22 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).