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ACAN / Aggrecan

aggrecan

This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.

Gene Name: aggrecan
Synonyms: ACAN, AGCAN, Aggrecan core protein, Acg1, Aggrecan, CSPG1, CSPGCP, CSPCP, AGC1, Aggrecan 1, Large aggregating proteoglycan, MSK16, SEDK, MCSPG
Target Sequences: NM_013227 NP_037359.3 P16112

Publications (5)

1
Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation. Little CB, Hughes CE, Curtis CL, Janusz MJ, Bohne R, Wang-Weigand S, Taiwo YO, Mitchell PG, Otterness IG, Flannery CR, Caterson B. Matrix biology : journal of the International Society for Matrix Biology. 2002 21:271-88. [PubMed:12009333]
2
A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs. Swearingen CA, Chambers MG, Lin C, Marimuthu J, Rito CJ, Carter QL, Dotzlaf J, Liu C, Chandrasekhar S, Duffin KL, Mitchell PG, Durham TB, Wiley MR, Thirunavukkarasu K. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2010 18:1159-66. (WB; Bovine, Human, Rat) [PubMed:20633676]
3
Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration. Yurube T, Takada T, Suzuki T, Kakutani K, Maeno K, Doita M, Kurosaka M, Nishida K. Arthritis research & therapy. 2012 14:R51. (IHC; Rat) [PubMed:22394620] [PMC:PMC3446417]
4
Atelocollagen promotes chondrogenic differentiation of human adipose-derived mesenchymal stem cells. Seon Ae Kim, Yoo Joon Sur, Mi-La Cho, Eun Jeong Go, Yun Hwan Kim, Asode Ananthram Shetty, Seok Jung Kim. Scientific reports. 2020 June;10:10678. [Full Text Article] [PubMed:32606308] [PMC:PMC7327030]
5
Chondrocytes From Osteoarthritic and Chondrocalcinosis Cartilage Represent Different Phenotypes. Franziska Meyer, Annalena Dittmann, Uwe Kornak, Maria Herbster, Thomas Pap, Christoph H Lohmann, Jessica Bertrand. Frontiers in cell and developmental biology. 2021 Apr;9:622287. [Full Text Article] [PubMed:33981699] [PMC:PMC8107373]
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Products
Proteins (11)
Recombinant (11)
ACAN / Aggrecan (11)
No (11)
GST (1)
GST, N-terminus (1)
His (5)
His, N-Terminal (1)
His-S (1)
His-T7 (1)
Bovine (1)
Human (6)
Mouse (2)
Rat (2)
E. coli (8)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (1)
Low endotoxin level (1)
ACAN / Aggrecan Protein - Recombinant Aggrecan By SDS-PAGE
Select
E. coli
His
20.0 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$3,361
Select
HEK 293 Cells
None
Less than 0.1 EU/µg protein (determined by LAL method).
This 672 amino acid recombinant protein with a C-terminal His tag has a predicted molecular mass of approximately 74.3 kD. The protein migrates at about 100 kD by SDS-PAGE in DTT-reducing and non-reducing conditions. The predicted N-terminal amino acid is
25 µg/$375; 100 µg/$731
Select
E. coli
His
14.1 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
ACAN / Aggrecan Protein - Recombinant Aggrecan (AGC) by SDS-PAGE
Select
E. coli
His, N-Terminal
23.7kDa
10 µg/$278; 50 µg/$422; 200 µg/$842; 100 µg/$672; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$3,361
ACAN / Aggrecan Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ACAN / Aggrecan Protein - Recombinant  Aggrecan By SDS-PAGE
Select
E. coli
His-T7
33.3 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
ACAN / Aggrecan Protein - 12.5% SDS-PAGE of human ACAN stained with Coomassie Blue
Select
Wheat Germ Extract
GST
106 kDa
2 µg/$439
Select
E. coli
His
12.2 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
ACAN / Aggrecan Protein - Recombinant Aggrecan By SDS-PAGE
Select
E. coli
His-S
18.2 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
ACAN / Aggrecan Protein - Recombinant Aggrecan By SDS-PAGE
Select
E. coli
His
14.1 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
Select
E. coli
His
12.3 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).