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ABRI / ITM2B

integral membrane protein 2B

Plays a regulatory role in the processing of the beta-amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites.Mature BRI2 (mBRI2) functions as a modulator of the beta-amyloid A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed beta-amyloid protein 40 and beta-amyloid protein 42.Bri23 peptide prevents aggregation of APP beta-amyloid protein 42 peptide into toxic oligomers.

Gene Name: integral membrane protein 2B
Synonyms: ITM2B, ABri/ADan amyloid peptide, ABRI, BRI, BRI2, E3-16, Integral membrane protein 2B, ImBRI2, FBD, Protein E25B, BRICD2B, BRICHOS domain containing 2B, Transmembrane protein BRI, E25B, Immature BRI2
Target Sequences: NM_021999 NP_068839.1 Q9Y287

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Products
Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
ABRI / ITM2B (7)
No (7)
6His, C-terminus (2)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (6)
293T Cells (1)
HEK 293 Cells (2)
Human Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (2)
Purified (1)
Low endotoxin level (2)
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
23.3kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
ABRI / ITM2B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
30.2 kDa
100 µg/$494
ABRI / ITM2B Protein - 12.5% SDS-PAGE of human ITM2B stained with Coomassie Blue
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Wheat Germ Extract
GST
56.7 kDa
10 µg/$479; 25 µg/$670
ABRI / ITM2B Protein - Purified recombinant protein ITM2B was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
30.2 kDa
20 µg/$1,107
ABRI / ITM2B Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Select
293T Cells
Myc-DDK (Flag)
30.2 kDa
20 µg/$150
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
23.3 kDa
10 µg/$317; 50 µg/$524
Viewing 1-7 of 7 product results


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Products: Proteins


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).