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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
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Additional Contact Details
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ABRI / ITM2B
integral membrane protein 2B
Plays a regulatory role in the processing of the beta-amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites.Mature BRI2 (mBRI2) functions as a modulator of the beta-amyloid A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed beta-amyloid protein 40 and beta-amyloid protein 42.Bri23 peptide prevents aggregation of APP beta-amyloid protein 42 peptide into toxic oligomers.
| Gene Name: | integral membrane protein 2B |
| Synonyms: | ITM2B, ABri/ADan amyloid peptide, ABRI, BRI, BRI2, E3-16, Integral membrane protein 2B, ImBRI2, FBD, Protein E25B, BRICD2B, BRICHOS domain containing 2B, Transmembrane protein BRI, E25B, Immature BRI2 |
| Target Sequences: | NM_021999 NP_068839.1 Q9Y287 |
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