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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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ABL2

c-abl oncogene 2, non-receptor tyrosine kinase

Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.

Gene Name: c-abl oncogene 2, non-receptor tyrosine kinase
Family/Subfamily: Protein Kinase , Abl
Synonyms: ABL2, Abl-related gene ARG, ABLL, Abelson-related gene protein, ARG, Oncogene abl2, Tyrosine-protein kinase ARG
Target Sequences: NM_007314 NP_009298.1 P42684

Viewing 1-25 of 45 items
ABL2 Antibody - Immunofluorescence of monoclonal antibody to ABL2 on HeLa cell (antibody concentration 10 ug/ml).
Select
Mouse Monoclonal [clone 5C6] (IgG3,k) to Human ABL2
Human
ELISA, IF, WB
Unconjugated
100µg   $365.00
ABL2 Antibody - Immunofluorescence staining of methanol-fixed HeLa cells using ABL2 mouse monoclonal antibody showing cytoplasm localization.
Select
Mouse Monoclonal [clone 1H1B11] (IgG1) to Human ABL2
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100µl   $315.00
Select
Rabbit Polyclonal (IgG) to Human ABL2
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100µg   $435.00
ABL2 Antibody - Immunohistochemistry of Arg antibody
Select
Rabbit Polyclonal (IgG) to Human ABL2
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
ABL2 Antibody - Abl2 Antibody in Immunofluorescence (IF)
Select
Mouse Monoclonal [clone 1H1] (IgG1) to Human ABL2
Mouse, Human
ICC, IF, WB
Unconjugated
100µl   $445.00
ABL2 Antibody - Immunofluorescence of NIH/3T3 cells using ABL2 mouse monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Select
Mouse Monoclonal [clone 1H1] (IgG1) to Human ABL2
Human
ELISA, IF, WB
Unconjugated
100µl   $345.00
ABL2 Antibody - Immunofluorescence (IF) analysis of NIH/3T3 cells using Arg Monoclonal Antibody (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Select
Mouse Monoclonal (IgG1) to Human ABL2
Mouse, Human
ELISA, IF, WB
Unconjugated
100µl   $345.00
ABL2 Antibody - Immunofluorescence (IF) staining of methanol-fixed HeLa cells using ABL2 Mouse Monoclonal Antibody showing cytoplasm localization using Arg Monoclonal Antibody.
Select
Mouse Monoclonal (IgG1) to Human ABL2
Human
ELISA, IF, WB
Unconjugated
100µl   $345.00
Select
Mouse Monoclonal (IgG1) to Human ABL2
Mouse, Human
ELISA, ICC, WB
Unconjugated
50µl   1mg/ml   $315.00; 100µl   1mg/ml   $375.00; 200µl   1mg/ml   $435.00
Select
Rabbit Polyclonal (IgG) to Human ABL2
Mouse, Human
ELISA, IHC, WB
Unconjugated
20µl   0.1mg/ml   $205.00; 60µl   0.1mg/ml   $235.00; 120µl   0.1mg/ml   $295.00; 200µl   0.1mg/ml   $395.00
Select
Rabbit Polyclonal (IgG) to Human ABL2
Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human ABL2
Human
ELISA, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ABL2
Human
ELISA, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ABL2
Human
ELISA, IHC, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ABL2
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ABL2
Human
ELISA, IHC, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ABL2
Human
ELISA, IHC, WB
APC Conjugated
200µl   $740.00
ABL2 Antibody - IHC analysis of ABL2 using anti-ABL2 antibody. ABL2 was detected in paraffin-embedded section of human lung cancer tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-ABL2 Antibody overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
Select
Rabbit Polyclonal to Human ABL2
Human
IHC, WB
Unconjugated
100µg   $355.00
ABL2 Antibody
Select
Rabbit Polyclonal (IgG) to Human ABL2
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100µg   $435.00
Select
Rabbit Polyclonal (IgG) to Human ABL2
Human
ELISA, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human ABL2
Human
ELISA, WB
Unconjugated
200µl   $590.00
ABL2 Antibody - Positive Western Blot detected in U87 whole cell lysate, U251 whole cell lysate. All lanes: ABL2 antibody at 4 µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 129, 125, 127, 115, 118, 116, 117, 61KDa. Observed band size: 125 KDa
Select
Rabbit Polyclonal (IgG) to Human ABL2
Human
ELISA, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
ABL2 Antibody - Western blot analysis of lysate from AD293 cells, using ABL2 Antibody.
Select
Rabbit Polyclonal (IgG) to Human ABL2
Mouse, Rat, Human
ELISA, WB
Unconjugated
50µg   1mg/ml   $265.00; 100µg   1mg/ml   $325.00
Select
Mouse Polyclonal (IgG) to Human ABL2
Mouse, Human
IHC, WB
Unconjugated
100µl   $295.00; 200µl   $385.00
ABL2 Antibody - Anti-ABL2 Antibody at 1:500 dilution + NIH/3T3 whole cell lysates Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 128 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Select
Mouse Monoclonal [clone 1442CT175.30.33] (IgG1,k) to Human ABL2
Mouse, Human
Peptide-ELISA, WB
Unconjugated
400µl   $325.00

Viewing 1-25 of 45 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).