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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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ABCC5 / MRP5

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

ABCC5 / MRP5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.

Gene Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 5
Family/Subfamily: Transporter , ATP-binding cassette - ABCC/MRP
Synonyms: ABCC5, ABC33, Abcc5a, MOATC, MRP5, PABC11, SMRP, EST277145, MOAT-C
Target Sequences: NM_005688 NP_005679.2 O15440

Publications (1)

1
Transporter function and cyclic AMP turnover in normal colonic mucosa from patients with and without colorectal neoplasia. Kleberg K, Jensen GM, Christensen DP, Lundh M, Grunnet LG, Knuhtsen S, Poulsen SS, Hansen MB, Bindslev N. BMC gastroenterology. 2012 12:78. (IHC; Human) [Full Text Article] [PubMed:22734885] [PMC:PMC3457850] Related Antibodies: LS-B2334.

Viewing 1-25 of 47 items
ABCC5 / MRP5 Antibody - Anti-ABCC5 / MRP5 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
(1) Publication(s)
Goat Polyclonal to Human ABCC5 / MRP5
Chicken, Bovine, Rabbit, Dog, Pig, Horse, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
ABCC5 / MRP5 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Mouse Monoclonal [clone 6C6] (IgG1) to Human ABCC5 / MRP5
Human
IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $425.00
Select
Rat Monoclonal [clone M5I-10] (IgG2a) to Mouse ABCC5 / MRP5
Mouse
ICC, IHC, IHC-Fr, WB
Unconjugated
1ml   $695.00
Select
Rat Monoclonal (IgG2a) to Human ABCC5 / MRP5
Human
ICC, WB
Unconjugated
250µg   $1,185.00
ABCC5 / MRP5 Antibody
Select
Rabbit Polyclonal (IgG) to Human ABCC5 / MRP5
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rat Monoclonal [clone M5I-1] (IgG2a) to Human ABCC5 / MRP5
Human
ICC, IHC, IHC-Fr, WB
Unconjugated, Concentrated
1ml   $455.00
Select
Rat Monoclonal [clone M5II-54] (IgG2a) to Human ABCC5 / MRP5
Human
ICC, IHC, IHC-Fr, WB
Unconjugated, Concentrated
1ml   $455.00
Select
Rat Monoclonal [clone M5I-10] (IgG2a) to Human ABCC5 / MRP5
Human
ICC, IHC, IHC-Fr, WB
Unconjugated, Concentrated
1ml   $455.00
ABCC5 / MRP5 Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-ABCC5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
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Mouse Monoclonal [clone OTI2C8] (IgG1) to Human ABCC5 / MRP5
Human
IHC, WB
Unconjugated
100µl   1mg/ml   $345.00
ABCC5 / MRP5 Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-ABCC5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
Select
Mouse Monoclonal [clone OTI2C8] (IgG1) to Human ABCC5 / MRP5
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
ABCC5 / MRP5 Antibody - Immunohistochemistry of paraffin-embedded Human ovarian cancer using ABCC5 Polyclonal Antibody at dilution of 1:50.
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Rabbit Polyclonal (IgG) to Human ABCC5 / MRP5
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20µl   0.5mg/ml   $205.00; 60µl   0.5mg/ml   $235.00; 120µl   0.5mg/ml   $295.00; 200µl   0.5mg/ml   $395.00
ABCC5 / MRP5 Antibody - Immunohistochemistry of paraffin-embedded Human lung cancer tissue using ABCC5 antibody.
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Rabbit Polyclonal (IgG) to Human ABCC5 / MRP5
Mouse, Rat, Human
IHC, WB
Unconjugated
50µl   $235.00; 100µl   $315.00; 200µl   $425.00
ABCC5 / MRP5 Antibody - Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Rabbit Polyclonal (IgG) to Human ABCC5 / MRP5
Human
ELISA, IHC, IHC-P
Unconjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human ABCC5 / MRP5
Human
ELISA, IHC
Unconjugated
100µg   $335.00
Select
Rabbit Polyclonal to Human ABCC5 / MRP5
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl   1mg/ml   $385.00
Select
Rabbit Polyclonal (IgG) to Human ABCC5 / MRP5
Rat, Human
IHC, WB
Unconjugated
50µl   $235.00; 100µl   $295.00; 200µl   $385.00
Select
Mouse Monoclonal (IgG2a,k) to Human ABCC5 / MRP5
Human
ELISA, WB
Unconjugated
100µg   $560.00
Select
Mouse Monoclonal (IgG2a,k) to Human ABCC5 / MRP5
Human
ELISA, WB
HRP Conjugated
100µl   $710.00
Select
Mouse Monoclonal (IgG2a,k) to Human ABCC5 / MRP5
Human
ELISA, WB
Biotin Conjugated
100µl   $710.00
Select
Mouse Monoclonal (IgG2a,k) to Human ABCC5 / MRP5
Human
ELISA, WB
FITC Conjugated
100µl   $710.00
Select
Mouse Monoclonal (IgG2a,k) to Human ABCC5 / MRP5
Human
ELISA, WB
PE Conjugated
100µl   $710.00
Select
Mouse Monoclonal (IgG2a,k) to Human ABCC5 / MRP5
Human
ELISA, WB
APC Conjugated
100µl   $710.00
Select
Mouse Monoclonal (IgG2a,k) to Human ABCC5 / MRP5
Human
ELISA, WB
AP Conjugated
100µl   $710.00
Select
Rabbit Polyclonal to Human ABCC5 / MRP5
Mouse, Human
ELISA, WB
Unconjugated
100µg   100µl   1mg/ml   $305.00
Select
Rabbit Polyclonal (IgG) to Human ABCC5 / MRP5
Human
ELISA, WB
Unconjugated
200µl   $590.00

Viewing 1-25 of 47 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).