AATF

apoptosis antagonizing transcription factor

May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

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Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

AATF (8)

Publications

No (8)

Tag

GST (2)

GST, N-terminus (1)

His-GST (2)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human AATF Protein (Recombinant GST) (Full Length) - LS-G33193

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

89.5 kDa

Price:

2 µg/$439

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AATF Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114568

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63 kDa

Price:

100 µg/$494

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Human AATF Protein (Recombinant GST) (aa6-294) - LS-G22273

Source:

E. coli

Tag:

GST

Molecular Weight:

59.1 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human AATF Protein (Recombinant GST, N-terminus) (aa151-250) - LS-G62194

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human AATF Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82671

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63 kDa

Price:

20 µg/$150

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Rat AATF Protein (Recombinant His-T7) (aa237-523) - LS-G12175

Source:

E. coli

Tag:

His-T7

Molecular Weight:

37.0 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human AATF Protein (Recombinant His-GST) (aa273-477) - LS-G12177

Source:

E. coli

Tag:

His-GST

Molecular Weight:

56.1 kDa

Price:

50 µg/$422; 10 µg/$278; 200 µg/$842; 100 µg/$672; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Mouse AATF Protein (Recombinant His-GST) (aa240-438) - LS-G12178

Source:

E. coli

Tag:

His-GST

Molecular Weight:

55.4 kDa

Price:

50 µg/$432; 10 µg/$279; 200 µg/$862; 100 µg/$690; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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