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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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AATF

apoptosis antagonizing transcription factor

May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

Gene Name: apoptosis antagonizing transcription factor
Family/Subfamily: Transcription factor , not assigned-Transcription factor
Synonyms: AATF, CHE1, DED, Rb-binding protein Che-1, CHE-1, Protein AATF
Target Sequences: NM_012138 NP_036270.1 Q9NY61

Viewing 1-25 of 60 items
AATF Antibody - Anti-AATF antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Mouse Monoclonal [clone 3C7] (IgG1,k) to Human AATF
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   $495.00
AATF Antibody - Anti-AATF antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Rabbit Polyclonal (IgG) to Human AATF
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $545.00
AATF Antibody - Immunohistochemical analysis of AATF staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
Rabbit Polyclonal to Human AATF
Human, Monkey
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100µl   1mg/ml   $245.00
AATF Antibody - A: Marker, B: Daudi Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human AATF
Guinea pig, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $325.00
AATF Antibody
Select
Rabbit Polyclonal (IgG) to Human AATF
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal (IgG) to Human AATF
Human
ELISA, IF, WB
Unconjugated
100µg   $405.00
AATF Antibody - AATF antibody ARP31867_P050-NP_036270-AATF (apoptosis antagonizing transcription factor) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human AATF
Rabbit, Dog, Horse, Human
IHC, IHC-P, WB
Unconjugated
100µl   0.5mg/ml   $365.00
AATF Antibody - AATF antibody ARP31867_P050-NP_036270-AATF (apoptosis antagonizing transcription factor) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human AATF
Rabbit, Dog, Horse, Gibbon, Human, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100µl   0.65mg/ml   $385.00
AATF Antibody - AATF antibody ARP31867_P050-NP_036270-AATF (apoptosis antagonizing transcription factor) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human AATF
Rabbit, Dog, Horse, Gibbon, Human, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100µl   1mg/ml   $385.00
AATF Antibody - AATF antibody ARP31867_P050-NP_036270-AATF (apoptosis antagonizing transcription factor) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human AATF
Rabbit, Dog, Horse, Gibbon, Human, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100µl   1mg/ml   $385.00
AATF Antibody - IHC image of AATF Antibody diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Rabbit Polyclonal (IgG) to Human AATF
Human
ELISA, IHC, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human AATF
Mouse, Human
ELISA, IHC, WB
HRP Conjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human AATF
Human
ELISA, IHC, WB
Biotin Conjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human AATF
Human
ELISA, IHC, WB
FITC Conjugated
50µg   $285.00; 100µg   $385.00
AATF Antibody - Immunohistochemistry of paraffin-embedded human small intestine tissue using ARPC2 Antibody at dilution of 1:100
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Rabbit Polyclonal (IgG) to Human AATF
Human
ELISA, IHC, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human AATF
Human
ELISA, IHC, WB
HRP Conjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human AATF
Human
ELISA, IHC, WB
Biotin Conjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human AATF
Human
ELISA, IHC, WB
FITC Conjugated
50µg   $285.00; 100µg   $385.00
AATF Antibody - Western blot of Che-1 antibody
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Rabbit Polyclonal (IgG) to Human AATF
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
AATF Antibody - Western blot analysis of extracts from HeLa cells, HepG2 cells, COLO205 cells and HUVEC cells, using AATF antibody.
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Rabbit Polyclonal (IgG) to Human AATF
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µg   $305.00
AATF Antibody - Western blot analysis of Mouse heart tissue and 231 cell, using AATF Polyclonal Antibody at dilution of 1:667.
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Rabbit Polyclonal (IgG) to Human AATF
Mouse, Rat, Human
ELISA, WB
Unconjugated
20µl   0.9mg/ml   $205.00; 60µl   0.9mg/ml   $235.00; 120µl   0.9mg/ml   $295.00; 200µl   0.9mg/ml   $395.00
AATF Antibody - Western blot analysis of immunized recombinant protein, using anti-AATF monoclonal antibody.
Select
Mouse Monoclonal [clone AATF2B6] (IgG1) to Human AATF
Human
DB, WB
Unconjugated
100µg   100µg/ml   $415.00
Select
Rabbit Polyclonal (IgG) to Human AATF
Human
IP, WB
Unconjugated
100µl   0.2mg/ml   $395.00
AATF Antibody - Western blot analysis of lysates from HeLa cells, HepG2 cells, COLO205 cells, and HUVEC cells, using AATF Antibody. The lane on the right is blocked with the synthesized peptide.
Select
Rabbit Polyclonal (IgG) to Human AATF
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
Select
Mouse Monoclonal (IgG1) to Human AATF
Human
WB
Unconjugated
100µg   $590.00

Viewing 1-25 of 60 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).