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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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AANAT

aralkylamine N-acetyltransferase

AANAT belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: aralkylamine N-acetyltransferase
Synonyms: AANAT, AA-NAT, DSPS, Serotonin N-acetyltransferase, SNAT, Serotonin acetylase
Target Sequences: NM_001088 NP_001079.1 Q16613

Publications (5)

1
cAmp regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87): a new cell line (1E7) provides evidence of intracellular AANAT activation. Coon SL, Weller JL, Korf HW, Namboodiri MA, Rollag M, Klein DC. The Journal of biological chemistry. 2001 276:24097-107. [PubMed:11313340]
2
Retinal melatonin production: role of proteasomal proteolysis in circadian and photic control of arylalkylamine N-acetyltransferase. Iuvone PM, Brown AD, Haque R, Weller J, Zawilska JB, Chaurasia SS, Ma M, Klein DC. Investigative ophthalmology & visual science. 2002 43:564-72. [PubMed:11818405]
3
14-3-3 Proteins and photoneuroendocrine transduction: role in controlling the daily rhythm in melatonin. Klein DC, Ganguly S, Coon S, Weller JL, Obsil T, Hickman A, Dyda F. Biochemical Society transactions. 2002 30:365-73. [PubMed:12196096]
4
Melatonin synthesis enzymes in Macaca mulatta: focus on arylalkylamine N-acetyltransferase (EC 2.3.1.87). Coon SL, Del Olmo E, Young WS, Klein DC. The Journal of clinical endocrinology and metabolism. 2002 87:4699-706. [PubMed:12364461]
5
Arylalkylamine N-acetyltransferase: "the Timezyme". Klein DC. The Journal of biological chemistry. 2007 282:4233-7. [PubMed:17164235]
more


AANAT Antibody - AANAT in COS7 and 1E7 cells detected by ICC.. Cells were grown on two-well chamber slides and fixed with 2.5% glutaraldehyde; 1E7 cells treated with FSK for 3 h (two magnifications). COS, COS7 cells treated with FSK for 3 h.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human AANAT
Human, Primate
IHC, WB
Unconjugated
100µl   $335.00
AANAT Antibody - AANAT in COS7 and 1E7 cells detected by ICC.. Cells were grown on two-well chamber slides and fixed with 2.5% glutaraldehyde; 1E7 cells treated with FSK for 3 h (two magnifications). COS, COS7 cells treated with FSK for 3 h.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human AANAT
Human, Primate
ICC, IHC, WB
Biotin Conjugated
100µl   $365.00
AANAT Antibody - AANAT in COS7 and 1E7 cells detected by ICC.. Cells were grown on two-well chamber slides and fixed with 2.5% glutaraldehyde; 1E7 cells treated with FSK for 3 h (two magnifications). COS, COS7 cells treated with FSK for 3 h.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human AANAT
Human, Primate
ICC, IHC, WB
DY650 Conjugated
100µl   $365.00
AANAT Antibody - AANAT in COS7 and 1E7 cells detected by ICC.. Cells were grown on two-well chamber slides and fixed with 2.5% glutaraldehyde; 1E7 cells treated with FSK for 3 h (two magnifications). COS, COS7 cells treated with FSK for 3 h.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human AANAT
Human, Primate
ICC, IHC, WB
DY488 Conjugated
100µl   $365.00
AANAT Antibody - AANAT in COS7 and 1E7 cells detected by ICC.. Cells were grown on two-well chamber slides and fixed with 2.5% glutaraldehyde; 1E7 cells treated with FSK for 3 h (two magnifications). COS, COS7 cells treated with FSK for 3 h.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human AANAT
Human, Primate
ICC, IHC, WB
DY550 Conjugated
100µl   $365.00
AANAT Antibody - Immunohistochemistry (IHC) analysis of AANAT antibody in paraffin-embedded human breast carcinoma tissue at 1:50, showing cytoplasmic strong positive staining. Negative control (the right) using PBS instead of primary antibody. Secondary antibody is Goat Anti-Rabbit IgG.
Select
Rabbit Polyclonal to Human AANAT
Rat, Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $385.00
AANAT Antibody - Immunohistochemistry of paraffin-embedded Human cervical cancer using AANAT Polyclonal Antibody at dilution of 1:40.
Select
Rabbit Polyclonal (IgG) to Human AANAT
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20µl   0.2mg/ml   $205.00; 60µl   0.2mg/ml   $235.00; 120µl   0.2mg/ml   $295.00; 200µl   0.2mg/ml   $395.00
AANAT Antibody - Immunofluorescence staining of A549 cells at a dilution of 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4 °C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L) .
Select
Rabbit Polyclonal (IgG) to Human AANAT
Human
ELISA, IF, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
AANAT Antibody - Immunohistochemistry of paraffin-embedded Human brain using AANAT Polyclonal Antibody at dilution of 1:40.
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Rabbit Polyclonal (IgG) to Human AANAT
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20µl   0.6mg/ml   $205.00; 60µl   0.6mg/ml   $235.00; 120µl   0.6mg/ml   $295.00; 200µl   0.6mg/ml   $395.00
Select
Rabbit Polyclonal to Mouse AANAT
Mouse
ICC, WB
FITC Conjugated
100µl   0.5mg/ml   $385.00
Select
Rabbit Polyclonal to Mouse AANAT
Mouse
ICC, WB
Biotin Conjugated
100µl   0.5mg/ml   $365.00
Select
Rabbit Polyclonal (IgG) to Human AANAT
Human
ELISA, WB
Unconjugated
100µg   $405.00
Select
Rabbit Polyclonal (IgG) to Human AANAT
Human
ELISA, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human AANAT
Human
ELISA, WB
HRP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human AANAT
Human
ELISA, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human AANAT
Human
ELISA, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human AANAT
Human
ELISA, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human AANAT
Human
ELISA, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human AANAT
Human
ELISA, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human AANAT
Human
IF
Unconjugated
20µl   $215.00; 50µl   $235.00; 100µl   $295.00; 200µl   $385.00
AANAT Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY AANAT. (Right lane) cDNA for 48 hrs and lysed
Select
Mouse Monoclonal [clone OTI6E1] (IgG1) to Human AANAT
Human
WB
Unconjugated
100µl   1mg/ml   $345.00
AANAT Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY AANAT. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-AANAT. (1:2000)
Select
Mouse Monoclonal [clone OTI6E1] (IgG1) to Human AANAT
Human
WB
Unconjugated, Carrier-free
100µg   $395.00
AANAT Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY AANAT. (Right lane) cDNA for 48 hrs and lysed
Select
Mouse Monoclonal [clone OTI3B9] (IgG1) to Human AANAT
Human
WB
Unconjugated
100µl   1mg/ml   $345.00
AANAT Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY AANAT. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-AANAT. (1:2000)
Select
Mouse Monoclonal [clone OTI3B9] (IgG1) to Human AANAT
Human
WB
Unconjugated, Carrier-free
100µg   $395.00
AANAT Antibody - Western blot analysis of AANAT expression in A549 (A); PC12 (B) whole cell lysates.
Select
Rabbit Polyclonal to Human AANAT
Mouse, Rat, Human
WB
Unconjugated
30µl   1mg/ml   $205.00; 100µl   1mg/ml   $245.00; 200µl   1mg/ml   $305.00
Viewing 1-25 of 37 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).