Recombinant Protein

Varicella Zoster Virus (VZV) Glycoprotein E (gE)

Varicella Zoster Virus

Unmodified

85.4 kDa

E. coli

E. coli

Greater than 85% by SDS-PAGE

Envelope glycoprotein that binds to the potential host cell entry receptor IDE. In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells. In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips

Not Tested

Not Tested

Lyophilized from 20 mM Tris-HCl, 0.15M NaCl, 0.05%Fos-12, 6% Trehalose, pH 8.0.

Briefly centrifuge vial prior to opening. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. Add 5-50% of glycerol (final concentration).

Short term: store at 4°C for up to 1 week. Long term: store at -20°C regardless of reconstitution; aliquot to avoid freeze-thaw cycles after reconstitution.

For research use only. Intended for use by laboratory professionals.

This protein carries the LSBio 100% Guarantee.