Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
4.5 U/mg protein. One unit will produce 1.0 micromole of hippuric acid from hippuryl-His-Leu per minute in 50 mM HEPES and 300 mM NaCl at pH 8.3 at 37°C. EDTA can be used as a strong inhibitor of this enzyme. This can be reversed by dialysis and reactivation with metal salts. The Km for this enzyme is 2.6 mM using hippuryl-L-histidyl-L-leucine as the substrate.
Store at -20°C only. Avoid freeze/thaw cycles. Store undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
ACE Protein, ACE1 Protein, Angiotensin-converting enzyme Protein, CD143 Protein, CD143 antigen Protein, Carboxycathepsin Protein, DIPEPTIDYL CARBOXYPEPTIDASE Protein, DCP Protein, Dipeptidyl carboxypeptidase I Protein, ICH Protein, Kininase II Protein, MVCD3 Protein, Peptidyl-dipeptidase A Protein, Peptidase P Protein, DCP1 Protein, Dipeptidyl carboxypeptidase 1 Protein, Testicular ECA Protein
ACE / CD143 is an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system.