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Catalog Number Size Price
LS-G49796-5 5 µg $255 
LS-G49796-100 100 µg $570 
LS-G49796-1 1 mg $3,099 
IL23 Protein - Measured by its ability to induce IL17 secretion by mouse splenocytes. The ED50 for this effect is 4-20 ng/mL.
IL23 Protein
IL23 Protein - Measured by its ability to induce IL17 secretion by mouse splenocytes. The ED50 for this effect is 4-20 ng/mL.
IL23 Protein
1 of 2
2 of 2

Human IL23 Protein (Recombinant His,C-terminus) (Met1-Pro189) - LS-G49796

Human IL23 Protein (Recombinant His,C-terminus) (Met1-Pro189) - LS-G49796

Description:
IL23 Protein LS-G49796 is a Recombinant Human IL23 produced in HEK 293 Cells Met1-Pro189 + Met1-Ser328 with His,C-terminus tag(s). It is biologically active and is low in endotoxin; Less than 1.0 EU/µg protein (determined by LAL method). For Research Use Only
Price
Catalog Number
$255
LS-G49796-5
Toll Free North America
206-374-1102
For Research Use Only

Overview

Description:
IL23 Protein LS-G49796 is a Recombinant Human IL23 produced in HEK 293 Cells Met1-Pro189 + Met1-Ser328 with His,C-terminus tag(s). It is biologically active and is low in endotoxin; Less than 1.0 EU/µg protein (determined by LAL method). For Research Use Only

Specifications

Type
Recombinant Protein
Target
IL23
Synonyms
IL23
Species
Human
Modifications
Unmodified
Conjugations
Unconjugated
Applications
  • Binding
  • ELISA
  • Functional Assay
  • Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis
Tag
His,C-terminus
Region
Met1-Pro189 + Met1-Ser328
Predicted Molecular Weight
The recombinant IL23 heterodimer of human IL23A/IL12B comprises 498 (181 + 317) amino acids and has a calculated molecular mass of 56.3 (20.1 + 36.2) kDa. The apparent molecular mass of rhIL23 heterodimer is approximately 22 & 45 kDa respectively in SDS-PAGE under reducing conditions.
Expression System
HEK 293 Cells
Source Species
Human
Purification
> 90 % as determined by SDS-PAGE
Bio-Activity
Measured by its ability to bind biotinylated recombinant human IL12RB1 in a functional ELISA. Measured by its binding ability in a functional ELISA. Immobilized human IL23A-His+IL12B-His at 10 µg/ml (100 µl/well) can bind human IL23R-Fc. The EC50 of human IL23R-Fc is 0.28-0.66 µg/ml. Measured by its binding ability in a functional ELISA. Immobilized human IL23A-His+IL12B-His at 10 µg/ml (100 µl/well) can bind Cynomolgus IL23R-Fc. The EC50 of Cynomolgus IL23R-Fc is 0.14-0.35 µg/ml. Measured by its ability to induce IL17 secretion by mouse splenocytes. The ED50 for this effect is 4-20 ng/mL.
Endotoxin
Less than 1.0 EU/µg protein (determined by LAL method).
Presentation
Lyophilized from sterile PBS, pH 7.4, with 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Reconstitution
Reconstituted with sterile deionized water to 0.25 mg/mL.
Storage
Aliquot and store at -20°C to -80°C for one year. Avoid repeated freeze-thaw cycles. Stable for 12 months.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This protein carries the LSBio 100% Guarantee.
LSBio Guarantee

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Functional Assay

IL23 Protein - Measured by its ability to induce IL17 secretion by mouse splenocytes. The ED50 for this effect is 4-20 ng/mL.
Measured by its ability to induce IL17 secretion by mouse splenocytes. The ED50 for this effect is 4-20 ng/mL.

Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis

IL23 Protein

Functional Assay

IL23 Protein - Measured by its ability to induce IL17 secretion by mouse splenocytes. The ED50 for this effect is 4-20 ng/mL.
Measured by its ability to induce IL17 secretion by mouse splenocytes. The ED50 for this effect is 4-20 ng/mL.

Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis

IL23 Protein

Functional Assay

IL23 Protein - Measured by its ability to induce IL17 secretion by mouse splenocytes. The ED50 for this effect is 4-20 ng/mL.
Measured by its ability to induce IL17 secretion by mouse splenocytes. The ED50 for this effect is 4-20 ng/mL.

Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis

IL23 Protein

Functional Assay

IL23 Protein - Measured by its ability to induce IL17 secretion by mouse splenocytes. The ED50 for this effect is 4-20 ng/mL.
Measured by its ability to induce IL17 secretion by mouse splenocytes. The ED50 for this effect is 4-20 ng/mL.

Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis

IL23 Protein

Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 7/13/2024