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PRKAR1A Recombinant Protein LS-G18421

Ordering

Wt. Vol. Conc. Price
1 µg - - $195
3 µg - - $255
100 µg - - $3,900
Inquire for larger quantities
LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular PRKAR1A Proteins

PRKAR1A Recombinant Protein - LS-G18421
E. coli Expression System
None
Unpurified / Lyophilized
Human PRKAR1A Recombinant Protein - LS-G18422
E. coli Expression System
None
Unpurified / Lyophilized
Human PRKAR1A Recombinant (6His,C-terminus) Protein - LS-G39993
Human Human Cells
6His,C-terminus
Unpurified

100% Guaranteed 100% Guaranteed
LS-G18421
Recombinant Protein
PRKAR1A
cAMP-dependent PKA is an ubiquitous serine/theonine protein kinase present in a variety of tissues (e.g. brain, skeletal muscle, heart). The intracellular cAMP level regulates cellular responses by altering the interaction between the catatytic C and regulatory R subunits of PKA. The inactive tetrameric PKA holoenzyme R2C2 is activated when cAMP binds to R2, which dissociates the tetramer to R2 cAMP 4 and two active catalytic subunits. Free Catalytic subunits of PKA can phosphorylate a wide variety of intracellular target proteins. In response to hormone- induced high cAMP levels, PKA phosphorylates glycogen synthetase (inhibition of the enzyme activity) and phosphorylase kinase to block glycogen synthesis. Different isoforms of catalytic and regulatory subunits suggest specific functions. The recombinant PKA regulatory subunit I a is a dimeric 90kDa protein.
E. coli
E. coli
None
Greater than 90% by SDS-PAGE
50% glycerol.
Store lyophilized at 4°C. Once reconstituted, aliquot and store at -20°C. Avoid freeze-thaw cycles.
For research use only.

About PRKAR1A

P10644 NM_002734 NP_002725.1

PRKAR1A Protein, ADOHR Protein, CNC Protein, ACRDYS1 Protein, TSE1 Protein, PRKAR1 Protein, Tissue specific extinguisher 1 Protein, Tissue-specific extinguisher 1 Protein, CAR Protein, CNC1 Protein, PKR1 Protein, PPNAD1 Protein

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.

Requested From: United States
Date Requested: 12/5/2016

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