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Human TOP1 / Topoisomerase I Recombinant (His) Protein LS-G17526

Ordering

Wt. Vol. Conc. Price
5 µg - - $195
20 µg - - $255
1 mg - - $4,095
Inquire for larger quantities
LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
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Most Popular TOP1 / Topoisomerase I Proteins

Human TOP1 / Topoisomerase I Recombinant (His) Protein - LS-G17293
Insect Sf9 Cells
His
Unpurified / Lyophilized
Human TOP1 / Topoisomerase I Recombinant (His) Protein - LS-G17526
Insect Sf9 Cells
His
Unpurified / Lyophilized
Bovine TOP1 / Topoisomerase I Protein - LS-G17875
Bovine Expression System
None
Unpurified / Lyophilized

100% Guaranteed 100% Guaranteed
LS-G17526
Recombinant Protein
TOP1 / Topoisomerase I
Human
DNA Topoisomerase-I Human Recombinant produced in SF9 is a glycosylated, polypeptide chain having a molecular mass of 91,576 Dalton (excluding glycosilation) 102 kDa total mass. The TOP1 is expressed with a -6xHis tag and purified by proprietary chromatographic techniques.
Sf9 Cells
Insect
His
Greater than 95% by SDS-PAGE
16 mM HEPES, pH 7.5, 16 mM NaCl, 20% glycerol.
Store lyophilized at 4°C. Once reconstituted, aliquot and store at -20°C. Avoid freeze-thaw cycles.
For research use only.

About TOP1 / Topoisomerase I

P11387 NM_003286 NP_003277.1

TOP1 Protein, DNA topoisomerase I Protein, DNA topoisomerase 1 Protein, TOPI Protein, Topoisomerase (DNA) I Protein, Topoisomerase I Protein, Type I DNA topoisomerase Protein

Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand.

Requested From: United States
Date Requested: 12/4/2016

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