Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Purified / Lyophilized / Endotoxin Level: Less than 1.0 EU/µg protein (determined by LAL method).
SMAD3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 445 amino acids (1-425) and having a molecular mass of 50.2 kDa. SMAD3 is fused to a 20 amino acid His-Tag at N-Terminus and purified by standard chromatography techniques.
Greater than 90% by SDS-PAGE
20 mM Tris-HCl, pH 8, 20 mM NaCl, 20 mM DTT, 20% Glycerol.
Store lyophilized at 4°C. Once reconstituted, aliquot and store at -20°C. Avoid freeze-thaw cycles.
SMAD3 Protein, HSPC193 Protein, HMAD-3 Protein, HsT17436 Protein, LDS1C Protein, LDS3 Protein, Mad homolog JV15-2 Protein, MAD3 Protein, MADH3 Protein, Mothers against DPP homolog 3 Protein, JV15-2 Protein, SMA- and MAD-related protein 3 Protein, SMAD family member 3 Protein, MAD homolog 3 Protein, HSMAD3 Protein, Mad protein homolog Protein, SMAD 3 Protein
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription.