Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
SMAD3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 445 amino acids (1-425) and having a molecular mass of 50.2 kDa. SMAD3 is fused to a 20 amino acid His-Tag at N-Terminus and purified by standard chromatography techniques.
Greater than 90% by SDS-PAGE
20 mM Tris-HCl, pH 8, 20 mM NaCl, 20 mM DTT, 20% Glycerol.
Store lyophilized at 4°C. Once reconstituted, aliquot and store at -20°C. Avoid freeze-thaw cycles.
SMAD3 Protein, HSPC193 Protein, HMAD-3 Protein, HsT17436 Protein, LDS1C Protein, LDS3 Protein, Mad homolog JV15-2 Protein, MAD3 Protein, MADH3 Protein, Mothers against DPP homolog 3 Protein, JV15-2 Protein, SMA- and MAD-related protein 3 Protein, SMAD family member 3 Protein, MAD homolog 3 Protein, HSMAD3 Protein, Mad protein homolog Protein, SMAD 3 Protein
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription.